Cargando…
Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report
Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor. It is widely used in the treatment of advanced non-small cell lung cancer and pancreatic cancer. However, there are currently no reports of the efficacy of erlotinib in patients with metastatic vaginal carcinoma. A 48-year-o...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919878/ https://www.ncbi.nlm.nih.gov/pubmed/24527088 http://dx.doi.org/10.3892/ol.2014.1805 |
_version_ | 1782303101147938816 |
---|---|
author | MA, QING REN, YAO-YAO LIU, XIA GONG, TING ZHONG, DIAN-SHENG |
author_facet | MA, QING REN, YAO-YAO LIU, XIA GONG, TING ZHONG, DIAN-SHENG |
author_sort | MA, QING |
collection | PubMed |
description | Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor. It is widely used in the treatment of advanced non-small cell lung cancer and pancreatic cancer. However, there are currently no reports of the efficacy of erlotinib in patients with metastatic vaginal carcinoma. A 48-year-old female with vaginal carcinoma was diagnosed with lung metastasis four years following surgery. The patient received three cycles of chemotherapy but could not tolerate further treatment due to the side effects. Next, erlotinib was administered, prompting a partial response and disease stabilization for 9 months prior to disease progression. While the main treatments for vaginal carcinoma with distant metastasis are chemotherapy and radiotherapy, this case supplies preliminary evidence that erlotinib may have activity in these patients. Further studies are required to determine the potential of this therapy. |
format | Online Article Text |
id | pubmed-3919878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-39198782014-02-13 Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report MA, QING REN, YAO-YAO LIU, XIA GONG, TING ZHONG, DIAN-SHENG Oncol Lett Articles Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor. It is widely used in the treatment of advanced non-small cell lung cancer and pancreatic cancer. However, there are currently no reports of the efficacy of erlotinib in patients with metastatic vaginal carcinoma. A 48-year-old female with vaginal carcinoma was diagnosed with lung metastasis four years following surgery. The patient received three cycles of chemotherapy but could not tolerate further treatment due to the side effects. Next, erlotinib was administered, prompting a partial response and disease stabilization for 9 months prior to disease progression. While the main treatments for vaginal carcinoma with distant metastasis are chemotherapy and radiotherapy, this case supplies preliminary evidence that erlotinib may have activity in these patients. Further studies are required to determine the potential of this therapy. D.A. Spandidos 2014-03 2014-01-15 /pmc/articles/PMC3919878/ /pubmed/24527088 http://dx.doi.org/10.3892/ol.2014.1805 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles MA, QING REN, YAO-YAO LIU, XIA GONG, TING ZHONG, DIAN-SHENG Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report |
title | Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report |
title_full | Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report |
title_fullStr | Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report |
title_full_unstemmed | Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report |
title_short | Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report |
title_sort | erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919878/ https://www.ncbi.nlm.nih.gov/pubmed/24527088 http://dx.doi.org/10.3892/ol.2014.1805 |
work_keys_str_mv | AT maqing erlotinibinapatientwithvaginalcarcinomaandpulmonarymetastasisacasereport AT renyaoyao erlotinibinapatientwithvaginalcarcinomaandpulmonarymetastasisacasereport AT liuxia erlotinibinapatientwithvaginalcarcinomaandpulmonarymetastasisacasereport AT gongting erlotinibinapatientwithvaginalcarcinomaandpulmonarymetastasisacasereport AT zhongdiansheng erlotinibinapatientwithvaginalcarcinomaandpulmonarymetastasisacasereport |