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Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report

Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor. It is widely used in the treatment of advanced non-small cell lung cancer and pancreatic cancer. However, there are currently no reports of the efficacy of erlotinib in patients with metastatic vaginal carcinoma. A 48-year-o...

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Autores principales: MA, QING, REN, YAO-YAO, LIU, XIA, GONG, TING, ZHONG, DIAN-SHENG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919878/
https://www.ncbi.nlm.nih.gov/pubmed/24527088
http://dx.doi.org/10.3892/ol.2014.1805
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author MA, QING
REN, YAO-YAO
LIU, XIA
GONG, TING
ZHONG, DIAN-SHENG
author_facet MA, QING
REN, YAO-YAO
LIU, XIA
GONG, TING
ZHONG, DIAN-SHENG
author_sort MA, QING
collection PubMed
description Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor. It is widely used in the treatment of advanced non-small cell lung cancer and pancreatic cancer. However, there are currently no reports of the efficacy of erlotinib in patients with metastatic vaginal carcinoma. A 48-year-old female with vaginal carcinoma was diagnosed with lung metastasis four years following surgery. The patient received three cycles of chemotherapy but could not tolerate further treatment due to the side effects. Next, erlotinib was administered, prompting a partial response and disease stabilization for 9 months prior to disease progression. While the main treatments for vaginal carcinoma with distant metastasis are chemotherapy and radiotherapy, this case supplies preliminary evidence that erlotinib may have activity in these patients. Further studies are required to determine the potential of this therapy.
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spelling pubmed-39198782014-02-13 Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report MA, QING REN, YAO-YAO LIU, XIA GONG, TING ZHONG, DIAN-SHENG Oncol Lett Articles Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor. It is widely used in the treatment of advanced non-small cell lung cancer and pancreatic cancer. However, there are currently no reports of the efficacy of erlotinib in patients with metastatic vaginal carcinoma. A 48-year-old female with vaginal carcinoma was diagnosed with lung metastasis four years following surgery. The patient received three cycles of chemotherapy but could not tolerate further treatment due to the side effects. Next, erlotinib was administered, prompting a partial response and disease stabilization for 9 months prior to disease progression. While the main treatments for vaginal carcinoma with distant metastasis are chemotherapy and radiotherapy, this case supplies preliminary evidence that erlotinib may have activity in these patients. Further studies are required to determine the potential of this therapy. D.A. Spandidos 2014-03 2014-01-15 /pmc/articles/PMC3919878/ /pubmed/24527088 http://dx.doi.org/10.3892/ol.2014.1805 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
MA, QING
REN, YAO-YAO
LIU, XIA
GONG, TING
ZHONG, DIAN-SHENG
Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report
title Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report
title_full Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report
title_fullStr Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report
title_full_unstemmed Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report
title_short Erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: A case report
title_sort erlotinib in a patient with vaginal carcinoma and pulmonary metastasis: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919878/
https://www.ncbi.nlm.nih.gov/pubmed/24527088
http://dx.doi.org/10.3892/ol.2014.1805
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