De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report

The t(3;12)(q26;p13) translocation is a recurrent chromosomal aberration observed in myeloid malignancies. The translocation results in the generation of the ETV6/myelodysplastic syndrome 1 (MDS1)/ectopic viral integration site 1 (EVI1) fusion gene. However, the present case report is the first to p...

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Autores principales: ACHKAR, WALID AL, ALJAPAWE, ABDULMUNIM, LIEHR, THOMAS, WAFA, ABDULSAMAD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919885/
https://www.ncbi.nlm.nih.gov/pubmed/24527086
http://dx.doi.org/10.3892/ol.2014.1784
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author ACHKAR, WALID AL
ALJAPAWE, ABDULMUNIM
LIEHR, THOMAS
WAFA, ABDULSAMAD
author_facet ACHKAR, WALID AL
ALJAPAWE, ABDULMUNIM
LIEHR, THOMAS
WAFA, ABDULSAMAD
author_sort ACHKAR, WALID AL
collection PubMed
description The t(3;12)(q26;p13) translocation is a recurrent chromosomal aberration observed in myeloid malignancies. The translocation results in the generation of the ETV6/myelodysplastic syndrome 1 (MDS1)/ectopic viral integration site 1 (EVI1) fusion gene. However, the present case report is the first to present this rearrangement in acute myelogeneous leukemia (AML)-M4. Notably, this case is the first report of AML-M4 with an initial trisomy 8 and secondary acquired t(3;12)(q26;p13). Cells harboring the t(3;12) translocation were found to exhibit a higher proliferative capacity than cells with pure trisomy 8, which is consistent with the role of the ETV6/MDS1/EVI1 fusion transcript in the development and progression of malignancy.
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spelling pubmed-39198852014-02-13 De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report ACHKAR, WALID AL ALJAPAWE, ABDULMUNIM LIEHR, THOMAS WAFA, ABDULSAMAD Oncol Lett Articles The t(3;12)(q26;p13) translocation is a recurrent chromosomal aberration observed in myeloid malignancies. The translocation results in the generation of the ETV6/myelodysplastic syndrome 1 (MDS1)/ectopic viral integration site 1 (EVI1) fusion gene. However, the present case report is the first to present this rearrangement in acute myelogeneous leukemia (AML)-M4. Notably, this case is the first report of AML-M4 with an initial trisomy 8 and secondary acquired t(3;12)(q26;p13). Cells harboring the t(3;12) translocation were found to exhibit a higher proliferative capacity than cells with pure trisomy 8, which is consistent with the role of the ETV6/MDS1/EVI1 fusion transcript in the development and progression of malignancy. D.A. Spandidos 2014-03 2014-01-08 /pmc/articles/PMC3919885/ /pubmed/24527086 http://dx.doi.org/10.3892/ol.2014.1784 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
ACHKAR, WALID AL
ALJAPAWE, ABDULMUNIM
LIEHR, THOMAS
WAFA, ABDULSAMAD
De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report
title De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report
title_full De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report
title_fullStr De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report
title_full_unstemmed De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report
title_short De novo acute myeloid leukemia subtype-M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report
title_sort de novo acute myeloid leukemia subtype-m4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to etv6/mds1/evi1 fusion transcript expression: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919885/
https://www.ncbi.nlm.nih.gov/pubmed/24527086
http://dx.doi.org/10.3892/ol.2014.1784
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