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Management of a patient with colon cancer and rotor syndrome: A case report

Rotor Syndrome (RS) is a rare disease that is autosomal recessive and characterized by asymptomatic jaundice, conjugated hyperbilirubinemia and coproporphyria. RS occurs as a result of a complete lack or partial defect of organic anion transporter polypeptides (OATPs) on the basolateral surface of h...

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Autores principales: ARSLAN, DENIZ, AVCI, FATMA, MERDIN, ALPARSLAN, GUNDUZ, SEYDA, COSKUN, HASAN SENOL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919936/
https://www.ncbi.nlm.nih.gov/pubmed/24520296
http://dx.doi.org/10.3892/ol.2013.1766
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author ARSLAN, DENIZ
AVCI, FATMA
MERDIN, ALPARSLAN
GUNDUZ, SEYDA
COSKUN, HASAN SENOL
author_facet ARSLAN, DENIZ
AVCI, FATMA
MERDIN, ALPARSLAN
GUNDUZ, SEYDA
COSKUN, HASAN SENOL
author_sort ARSLAN, DENIZ
collection PubMed
description Rotor Syndrome (RS) is a rare disease that is autosomal recessive and characterized by asymptomatic jaundice, conjugated hyperbilirubinemia and coproporphyria. RS occurs as a result of a complete lack or partial defect of organic anion transporter polypeptides (OATPs) on the basolateral surface of hepatocytes. OATPs facilitate the excretion of bilirubin and organic anions from the liver to the bile. To the best of our knowledge, there is no information in the literature relating to the treatment of a patient with colon cancer and RS. The present study aimed to discuss the systematic chemotherapy that is used and the effects on a 45-year-old patient who had RS with asymptomatic jaundice and was diagnosed with colon adenocarcinoma following surgery. The patient was administered oxaliplatin in combination with capecitabine. The patient’s biluribin level increased after one week. Capecitabine treatment was interrupted and the patient was administered oxaliplatin monotherapy. No significant toxicity was observed during that period. At the latest follow-up the patient did not exhibit any progression.
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spelling pubmed-39199362014-02-11 Management of a patient with colon cancer and rotor syndrome: A case report ARSLAN, DENIZ AVCI, FATMA MERDIN, ALPARSLAN GUNDUZ, SEYDA COSKUN, HASAN SENOL Oncol Lett Articles Rotor Syndrome (RS) is a rare disease that is autosomal recessive and characterized by asymptomatic jaundice, conjugated hyperbilirubinemia and coproporphyria. RS occurs as a result of a complete lack or partial defect of organic anion transporter polypeptides (OATPs) on the basolateral surface of hepatocytes. OATPs facilitate the excretion of bilirubin and organic anions from the liver to the bile. To the best of our knowledge, there is no information in the literature relating to the treatment of a patient with colon cancer and RS. The present study aimed to discuss the systematic chemotherapy that is used and the effects on a 45-year-old patient who had RS with asymptomatic jaundice and was diagnosed with colon adenocarcinoma following surgery. The patient was administered oxaliplatin in combination with capecitabine. The patient’s biluribin level increased after one week. Capecitabine treatment was interrupted and the patient was administered oxaliplatin monotherapy. No significant toxicity was observed during that period. At the latest follow-up the patient did not exhibit any progression. D.A. Spandidos 2014-03 2013-12-19 /pmc/articles/PMC3919936/ /pubmed/24520296 http://dx.doi.org/10.3892/ol.2013.1766 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
ARSLAN, DENIZ
AVCI, FATMA
MERDIN, ALPARSLAN
GUNDUZ, SEYDA
COSKUN, HASAN SENOL
Management of a patient with colon cancer and rotor syndrome: A case report
title Management of a patient with colon cancer and rotor syndrome: A case report
title_full Management of a patient with colon cancer and rotor syndrome: A case report
title_fullStr Management of a patient with colon cancer and rotor syndrome: A case report
title_full_unstemmed Management of a patient with colon cancer and rotor syndrome: A case report
title_short Management of a patient with colon cancer and rotor syndrome: A case report
title_sort management of a patient with colon cancer and rotor syndrome: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919936/
https://www.ncbi.nlm.nih.gov/pubmed/24520296
http://dx.doi.org/10.3892/ol.2013.1766
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