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Relation of Callosal Structure to Cognitive Abilities in Temporal Lobe Epilepsy

The main objective of this paper is to analyze the influence of mesial temporal lobe epilepsy (mTLE) on the morphology of the corpus callosum (CC) and its relation to cognitive abilities. More specifically, we investigated correlations between intellectual abilities and callosal morphology, while ad...

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Autores principales: Schneider, Christine, Helmstaedter, Christoph, Luders, Eileen, Thompson, Paul M., Toga, Arthur W., Elger, Christian, Weber, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920113/
https://www.ncbi.nlm.nih.gov/pubmed/24575078
http://dx.doi.org/10.3389/fneur.2014.00016
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author Schneider, Christine
Helmstaedter, Christoph
Luders, Eileen
Thompson, Paul M.
Toga, Arthur W.
Elger, Christian
Weber, Bernd
author_facet Schneider, Christine
Helmstaedter, Christoph
Luders, Eileen
Thompson, Paul M.
Toga, Arthur W.
Elger, Christian
Weber, Bernd
author_sort Schneider, Christine
collection PubMed
description The main objective of this paper is to analyze the influence of mesial temporal lobe epilepsy (mTLE) on the morphology of the corpus callosum (CC) and its relation to cognitive abilities. More specifically, we investigated correlations between intellectual abilities and callosal morphology, while additionally exploring the modulating impact of (a) side of seizure onset (b) age of disease onset. For this reason a large representative sample of patients with hippocampal sclerosis (n = 79; 35 males; 44 females; age: 18–63 years) with disease onset ranging from 0 to 50 years of age, and consisting of 46 left and 33 right mTLE-patients was recruited. Intelligence was measured using the Wechsler-Adult Intelligence Scale Revised. To get localizations of correlations with high anatomic precision, callosal morphology was examined using computational mesh-based modeling methods, applied to anatomical brain MRI scans. Intellectual performance was positively associated with callosal thickness in anterior and midcallosal callosal regions, with anterior parts being slightly more affected by age of disease onset and side of seizure onset than posterior parts. Earlier age at onset of epilepsy was associated with lower thickness in anterior and midcallosal regions. In addition, laterality of seizure onset had a significant influence on anterior CC morphology, with left hemispheric origin having stronger effects. We found that in mTLE, anterior and midcallosal CC morphology are related to cognitive performance. The findings support recent findings of detrimental effects of early onset mTLE on anterior brain regions and of a distinct effect particularly of left mTLE on frontal lobe functioning and structure. The causal nature of the relationship remains an open question, i.e., whether CC morphology impacts IQ development or whether IQ development impacts CC morphology, or both.
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spelling pubmed-39201132014-02-26 Relation of Callosal Structure to Cognitive Abilities in Temporal Lobe Epilepsy Schneider, Christine Helmstaedter, Christoph Luders, Eileen Thompson, Paul M. Toga, Arthur W. Elger, Christian Weber, Bernd Front Neurol Neuroscience The main objective of this paper is to analyze the influence of mesial temporal lobe epilepsy (mTLE) on the morphology of the corpus callosum (CC) and its relation to cognitive abilities. More specifically, we investigated correlations between intellectual abilities and callosal morphology, while additionally exploring the modulating impact of (a) side of seizure onset (b) age of disease onset. For this reason a large representative sample of patients with hippocampal sclerosis (n = 79; 35 males; 44 females; age: 18–63 years) with disease onset ranging from 0 to 50 years of age, and consisting of 46 left and 33 right mTLE-patients was recruited. Intelligence was measured using the Wechsler-Adult Intelligence Scale Revised. To get localizations of correlations with high anatomic precision, callosal morphology was examined using computational mesh-based modeling methods, applied to anatomical brain MRI scans. Intellectual performance was positively associated with callosal thickness in anterior and midcallosal callosal regions, with anterior parts being slightly more affected by age of disease onset and side of seizure onset than posterior parts. Earlier age at onset of epilepsy was associated with lower thickness in anterior and midcallosal regions. In addition, laterality of seizure onset had a significant influence on anterior CC morphology, with left hemispheric origin having stronger effects. We found that in mTLE, anterior and midcallosal CC morphology are related to cognitive performance. The findings support recent findings of detrimental effects of early onset mTLE on anterior brain regions and of a distinct effect particularly of left mTLE on frontal lobe functioning and structure. The causal nature of the relationship remains an open question, i.e., whether CC morphology impacts IQ development or whether IQ development impacts CC morphology, or both. Frontiers Media S.A. 2014-02-11 /pmc/articles/PMC3920113/ /pubmed/24575078 http://dx.doi.org/10.3389/fneur.2014.00016 Text en Copyright © 2014 Schneider, Helmstaedter, Luders, Thompson, Toga, Elger and Weber. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Schneider, Christine
Helmstaedter, Christoph
Luders, Eileen
Thompson, Paul M.
Toga, Arthur W.
Elger, Christian
Weber, Bernd
Relation of Callosal Structure to Cognitive Abilities in Temporal Lobe Epilepsy
title Relation of Callosal Structure to Cognitive Abilities in Temporal Lobe Epilepsy
title_full Relation of Callosal Structure to Cognitive Abilities in Temporal Lobe Epilepsy
title_fullStr Relation of Callosal Structure to Cognitive Abilities in Temporal Lobe Epilepsy
title_full_unstemmed Relation of Callosal Structure to Cognitive Abilities in Temporal Lobe Epilepsy
title_short Relation of Callosal Structure to Cognitive Abilities in Temporal Lobe Epilepsy
title_sort relation of callosal structure to cognitive abilities in temporal lobe epilepsy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920113/
https://www.ncbi.nlm.nih.gov/pubmed/24575078
http://dx.doi.org/10.3389/fneur.2014.00016
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