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Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors

WWOX, a gene that spans the second most common chromosomal fragile site (FRA16D), often exhibits homozygous deletions and translocation breakpoints under multiple cellular stresses induced by extrinsic or intrinsic factors, such as hypoxia, UV, and DNA damage regents. Loss of WWOX is closely related...

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Detalles Bibliográficos
Autores principales: Li, Juan, Liu, Jie, Ren, Yu, Yang, Jin, Liu, Peijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920169/
https://www.ncbi.nlm.nih.gov/pubmed/24520212
http://dx.doi.org/10.7150/ijbs.7727