Cargando…
Neurological Disorders in a Murine Model of Chronic Renal Failure
Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF). However, data on the impact of CRF on the cerebral circulatory system are scarce—despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. In the present study, we e...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920256/ https://www.ncbi.nlm.nih.gov/pubmed/24394639 http://dx.doi.org/10.3390/toxins6010180 |
_version_ | 1782303143099367424 |
---|---|
author | Chillon, Jean-Marc Brazier, François Bouquet, Philippe Massy, Ziad A. |
author_facet | Chillon, Jean-Marc Brazier, François Bouquet, Philippe Massy, Ziad A. |
author_sort | Chillon, Jean-Marc |
collection | PubMed |
description | Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF). However, data on the impact of CRF on the cerebral circulatory system are scarce—despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. In the present study, we examined the impact of CRF on behavior (anxiety), recognition and ischemic stroke severity in a well-defined murine model of CRF. We did not observe any significant increases between CRF mice and non-CRF mice in terms of anxiety. In contrast, CRF mice showed lower levels of anxiety in some tests. Recognition was not impaired (vs. controls) after 6 weeks of CRF but was impaired after 10 weeks of CRF. Chronic renal failure enhances the severity of ischemic stroke, as evaluated by the infarct volume size in CRF mice after 34 weeks of CRF. Furthermore, neurological test results in non-CRF mice tended to improve in the days following ischemic stroke, whereas the results in CRF mice tended to worsen. In conclusion, we showed that a murine model of CRF is suitable for evaluating uremic toxicity and the associated neurological disorders. Our data confirm the role of uremic toxicity in the genesis of neurological abnormalities (other than anxiety). |
format | Online Article Text |
id | pubmed-3920256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-39202562014-02-11 Neurological Disorders in a Murine Model of Chronic Renal Failure Chillon, Jean-Marc Brazier, François Bouquet, Philippe Massy, Ziad A. Toxins (Basel) Article Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF). However, data on the impact of CRF on the cerebral circulatory system are scarce—despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. In the present study, we examined the impact of CRF on behavior (anxiety), recognition and ischemic stroke severity in a well-defined murine model of CRF. We did not observe any significant increases between CRF mice and non-CRF mice in terms of anxiety. In contrast, CRF mice showed lower levels of anxiety in some tests. Recognition was not impaired (vs. controls) after 6 weeks of CRF but was impaired after 10 weeks of CRF. Chronic renal failure enhances the severity of ischemic stroke, as evaluated by the infarct volume size in CRF mice after 34 weeks of CRF. Furthermore, neurological test results in non-CRF mice tended to improve in the days following ischemic stroke, whereas the results in CRF mice tended to worsen. In conclusion, we showed that a murine model of CRF is suitable for evaluating uremic toxicity and the associated neurological disorders. Our data confirm the role of uremic toxicity in the genesis of neurological abnormalities (other than anxiety). MDPI 2014-01-03 /pmc/articles/PMC3920256/ /pubmed/24394639 http://dx.doi.org/10.3390/toxins6010180 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Chillon, Jean-Marc Brazier, François Bouquet, Philippe Massy, Ziad A. Neurological Disorders in a Murine Model of Chronic Renal Failure |
title | Neurological Disorders in a Murine Model of Chronic Renal Failure |
title_full | Neurological Disorders in a Murine Model of Chronic Renal Failure |
title_fullStr | Neurological Disorders in a Murine Model of Chronic Renal Failure |
title_full_unstemmed | Neurological Disorders in a Murine Model of Chronic Renal Failure |
title_short | Neurological Disorders in a Murine Model of Chronic Renal Failure |
title_sort | neurological disorders in a murine model of chronic renal failure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920256/ https://www.ncbi.nlm.nih.gov/pubmed/24394639 http://dx.doi.org/10.3390/toxins6010180 |
work_keys_str_mv | AT chillonjeanmarc neurologicaldisordersinamurinemodelofchronicrenalfailure AT brazierfrancois neurologicaldisordersinamurinemodelofchronicrenalfailure AT bouquetphilippe neurologicaldisordersinamurinemodelofchronicrenalfailure AT massyziada neurologicaldisordersinamurinemodelofchronicrenalfailure |