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Neurological Disorders in a Murine Model of Chronic Renal Failure

Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF). However, data on the impact of CRF on the cerebral circulatory system are scarce—despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. In the present study, we e...

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Autores principales: Chillon, Jean-Marc, Brazier, François, Bouquet, Philippe, Massy, Ziad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920256/
https://www.ncbi.nlm.nih.gov/pubmed/24394639
http://dx.doi.org/10.3390/toxins6010180
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author Chillon, Jean-Marc
Brazier, François
Bouquet, Philippe
Massy, Ziad A.
author_facet Chillon, Jean-Marc
Brazier, François
Bouquet, Philippe
Massy, Ziad A.
author_sort Chillon, Jean-Marc
collection PubMed
description Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF). However, data on the impact of CRF on the cerebral circulatory system are scarce—despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. In the present study, we examined the impact of CRF on behavior (anxiety), recognition and ischemic stroke severity in a well-defined murine model of CRF. We did not observe any significant increases between CRF mice and non-CRF mice in terms of anxiety. In contrast, CRF mice showed lower levels of anxiety in some tests. Recognition was not impaired (vs. controls) after 6 weeks of CRF but was impaired after 10 weeks of CRF. Chronic renal failure enhances the severity of ischemic stroke, as evaluated by the infarct volume size in CRF mice after 34 weeks of CRF. Furthermore, neurological test results in non-CRF mice tended to improve in the days following ischemic stroke, whereas the results in CRF mice tended to worsen. In conclusion, we showed that a murine model of CRF is suitable for evaluating uremic toxicity and the associated neurological disorders. Our data confirm the role of uremic toxicity in the genesis of neurological abnormalities (other than anxiety).
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spelling pubmed-39202562014-02-11 Neurological Disorders in a Murine Model of Chronic Renal Failure Chillon, Jean-Marc Brazier, François Bouquet, Philippe Massy, Ziad A. Toxins (Basel) Article Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF). However, data on the impact of CRF on the cerebral circulatory system are scarce—despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. In the present study, we examined the impact of CRF on behavior (anxiety), recognition and ischemic stroke severity in a well-defined murine model of CRF. We did not observe any significant increases between CRF mice and non-CRF mice in terms of anxiety. In contrast, CRF mice showed lower levels of anxiety in some tests. Recognition was not impaired (vs. controls) after 6 weeks of CRF but was impaired after 10 weeks of CRF. Chronic renal failure enhances the severity of ischemic stroke, as evaluated by the infarct volume size in CRF mice after 34 weeks of CRF. Furthermore, neurological test results in non-CRF mice tended to improve in the days following ischemic stroke, whereas the results in CRF mice tended to worsen. In conclusion, we showed that a murine model of CRF is suitable for evaluating uremic toxicity and the associated neurological disorders. Our data confirm the role of uremic toxicity in the genesis of neurological abnormalities (other than anxiety). MDPI 2014-01-03 /pmc/articles/PMC3920256/ /pubmed/24394639 http://dx.doi.org/10.3390/toxins6010180 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chillon, Jean-Marc
Brazier, François
Bouquet, Philippe
Massy, Ziad A.
Neurological Disorders in a Murine Model of Chronic Renal Failure
title Neurological Disorders in a Murine Model of Chronic Renal Failure
title_full Neurological Disorders in a Murine Model of Chronic Renal Failure
title_fullStr Neurological Disorders in a Murine Model of Chronic Renal Failure
title_full_unstemmed Neurological Disorders in a Murine Model of Chronic Renal Failure
title_short Neurological Disorders in a Murine Model of Chronic Renal Failure
title_sort neurological disorders in a murine model of chronic renal failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920256/
https://www.ncbi.nlm.nih.gov/pubmed/24394639
http://dx.doi.org/10.3390/toxins6010180
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