The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases

The Cytotoxic Necrotizing Factor 1 (CNF1), a protein toxin from pathogenic E. coli, modulates the Rho GTPases, thus, directing the organization of the actin cytoskeleton. In the nervous system, the Rho GTPases play a key role in several processes, controlling the morphogenesis of dendritic spines an...

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Autores principales: Travaglione, Sara, Loizzo, Stefano, Ballan, Giulia, Fiorentini, Carla, Fabbri, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920261/
https://www.ncbi.nlm.nih.gov/pubmed/24402235
http://dx.doi.org/10.3390/toxins6010270
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author Travaglione, Sara
Loizzo, Stefano
Ballan, Giulia
Fiorentini, Carla
Fabbri, Alessia
author_facet Travaglione, Sara
Loizzo, Stefano
Ballan, Giulia
Fiorentini, Carla
Fabbri, Alessia
author_sort Travaglione, Sara
collection PubMed
description The Cytotoxic Necrotizing Factor 1 (CNF1), a protein toxin from pathogenic E. coli, modulates the Rho GTPases, thus, directing the organization of the actin cytoskeleton. In the nervous system, the Rho GTPases play a key role in several processes, controlling the morphogenesis of dendritic spines and synaptic plasticity in brain tissues. This review is focused on the peculiar property of CNF1 to enhance brain plasticity in in vivo animal models of central nervous system (CNS) diseases, and on its possible application in therapy.
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spelling pubmed-39202612014-02-11 The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases Travaglione, Sara Loizzo, Stefano Ballan, Giulia Fiorentini, Carla Fabbri, Alessia Toxins (Basel) Article The Cytotoxic Necrotizing Factor 1 (CNF1), a protein toxin from pathogenic E. coli, modulates the Rho GTPases, thus, directing the organization of the actin cytoskeleton. In the nervous system, the Rho GTPases play a key role in several processes, controlling the morphogenesis of dendritic spines and synaptic plasticity in brain tissues. This review is focused on the peculiar property of CNF1 to enhance brain plasticity in in vivo animal models of central nervous system (CNS) diseases, and on its possible application in therapy. MDPI 2014-01-07 /pmc/articles/PMC3920261/ /pubmed/24402235 http://dx.doi.org/10.3390/toxins6010270 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Travaglione, Sara
Loizzo, Stefano
Ballan, Giulia
Fiorentini, Carla
Fabbri, Alessia
The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases
title The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases
title_full The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases
title_fullStr The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases
title_full_unstemmed The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases
title_short The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases
title_sort e. coli cnf1 as a pioneering therapy for the central nervous system diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920261/
https://www.ncbi.nlm.nih.gov/pubmed/24402235
http://dx.doi.org/10.3390/toxins6010270
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