Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential
Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920477/ https://www.ncbi.nlm.nih.gov/pubmed/24515248 http://dx.doi.org/10.1038/srep04061 |
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author | Choo, Siew Woh Wee, Wei Yee Ngeow, Yun Fong Mitchell, Wayne Tan, Joon Liang Wong, Guat Jah Zhao, Yongbing Xiao, Jingfa |
author_facet | Choo, Siew Woh Wee, Wei Yee Ngeow, Yun Fong Mitchell, Wayne Tan, Joon Liang Wong, Guat Jah Zhao, Yongbing Xiao, Jingfa |
author_sort | Choo, Siew Woh |
collection | PubMed |
description | Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes indicating an open, non-conservative pan-genome structure, and clear evidence of rapid phage-mediated evolution. Although we found fewer virulence factors in Ma compared to M. tuberculosis, our data indicated that Ma evolves rapidly and therefore should be monitored closely for the acquisition of more pathogenic traits. This comparative study provides a better understanding of Ma and forms the basis for future functional work on this important pathogen. |
format | Online Article Text |
id | pubmed-3920477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-39204772014-02-13 Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential Choo, Siew Woh Wee, Wei Yee Ngeow, Yun Fong Mitchell, Wayne Tan, Joon Liang Wong, Guat Jah Zhao, Yongbing Xiao, Jingfa Sci Rep Article Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes indicating an open, non-conservative pan-genome structure, and clear evidence of rapid phage-mediated evolution. Although we found fewer virulence factors in Ma compared to M. tuberculosis, our data indicated that Ma evolves rapidly and therefore should be monitored closely for the acquisition of more pathogenic traits. This comparative study provides a better understanding of Ma and forms the basis for future functional work on this important pathogen. Nature Publishing Group 2014-02-11 /pmc/articles/PMC3920477/ /pubmed/24515248 http://dx.doi.org/10.1038/srep04061 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Choo, Siew Woh Wee, Wei Yee Ngeow, Yun Fong Mitchell, Wayne Tan, Joon Liang Wong, Guat Jah Zhao, Yongbing Xiao, Jingfa Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential |
title | Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential |
title_full | Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential |
title_fullStr | Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential |
title_full_unstemmed | Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential |
title_short | Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential |
title_sort | genomic reconnaissance of clinical isolates of emerging human pathogen mycobacterium abscessus reveals high evolutionary potential |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920477/ https://www.ncbi.nlm.nih.gov/pubmed/24515248 http://dx.doi.org/10.1038/srep04061 |
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