Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential

Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes...

Descripción completa

Detalles Bibliográficos
Autores principales: Choo, Siew Woh, Wee, Wei Yee, Ngeow, Yun Fong, Mitchell, Wayne, Tan, Joon Liang, Wong, Guat Jah, Zhao, Yongbing, Xiao, Jingfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920477/
https://www.ncbi.nlm.nih.gov/pubmed/24515248
http://dx.doi.org/10.1038/srep04061
_version_ 1782303176408432640
author Choo, Siew Woh
Wee, Wei Yee
Ngeow, Yun Fong
Mitchell, Wayne
Tan, Joon Liang
Wong, Guat Jah
Zhao, Yongbing
Xiao, Jingfa
author_facet Choo, Siew Woh
Wee, Wei Yee
Ngeow, Yun Fong
Mitchell, Wayne
Tan, Joon Liang
Wong, Guat Jah
Zhao, Yongbing
Xiao, Jingfa
author_sort Choo, Siew Woh
collection PubMed
description Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes indicating an open, non-conservative pan-genome structure, and clear evidence of rapid phage-mediated evolution. Although we found fewer virulence factors in Ma compared to M. tuberculosis, our data indicated that Ma evolves rapidly and therefore should be monitored closely for the acquisition of more pathogenic traits. This comparative study provides a better understanding of Ma and forms the basis for future functional work on this important pathogen.
format Online
Article
Text
id pubmed-3920477
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-39204772014-02-13 Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential Choo, Siew Woh Wee, Wei Yee Ngeow, Yun Fong Mitchell, Wayne Tan, Joon Liang Wong, Guat Jah Zhao, Yongbing Xiao, Jingfa Sci Rep Article Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes indicating an open, non-conservative pan-genome structure, and clear evidence of rapid phage-mediated evolution. Although we found fewer virulence factors in Ma compared to M. tuberculosis, our data indicated that Ma evolves rapidly and therefore should be monitored closely for the acquisition of more pathogenic traits. This comparative study provides a better understanding of Ma and forms the basis for future functional work on this important pathogen. Nature Publishing Group 2014-02-11 /pmc/articles/PMC3920477/ /pubmed/24515248 http://dx.doi.org/10.1038/srep04061 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Choo, Siew Woh
Wee, Wei Yee
Ngeow, Yun Fong
Mitchell, Wayne
Tan, Joon Liang
Wong, Guat Jah
Zhao, Yongbing
Xiao, Jingfa
Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential
title Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential
title_full Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential
title_fullStr Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential
title_full_unstemmed Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential
title_short Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential
title_sort genomic reconnaissance of clinical isolates of emerging human pathogen mycobacterium abscessus reveals high evolutionary potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920477/
https://www.ncbi.nlm.nih.gov/pubmed/24515248
http://dx.doi.org/10.1038/srep04061
work_keys_str_mv AT choosiewwoh genomicreconnaissanceofclinicalisolatesofemerginghumanpathogenmycobacteriumabscessusrevealshighevolutionarypotential
AT weeweiyee genomicreconnaissanceofclinicalisolatesofemerginghumanpathogenmycobacteriumabscessusrevealshighevolutionarypotential
AT ngeowyunfong genomicreconnaissanceofclinicalisolatesofemerginghumanpathogenmycobacteriumabscessusrevealshighevolutionarypotential
AT mitchellwayne genomicreconnaissanceofclinicalisolatesofemerginghumanpathogenmycobacteriumabscessusrevealshighevolutionarypotential
AT tanjoonliang genomicreconnaissanceofclinicalisolatesofemerginghumanpathogenmycobacteriumabscessusrevealshighevolutionarypotential
AT wongguatjah genomicreconnaissanceofclinicalisolatesofemerginghumanpathogenmycobacteriumabscessusrevealshighevolutionarypotential
AT zhaoyongbing genomicreconnaissanceofclinicalisolatesofemerginghumanpathogenmycobacteriumabscessusrevealshighevolutionarypotential
AT xiaojingfa genomicreconnaissanceofclinicalisolatesofemerginghumanpathogenmycobacteriumabscessusrevealshighevolutionarypotential