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Small molecule-mediated refolding and activation of myosin motor function

The small molecule EMD 57033 has been shown to stimulate the actomyosin ATPase activity and contractility of myofilaments. Here, we show that EMD 57033 binds to an allosteric pocket in the myosin motor domain. EMD 57033-binding protects myosin against heat stress and thermal denaturation. In the pre...

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Detalles Bibliográficos
Autores principales:	Radke, Michael B, Taft, Manuel H, Stapel, Britta, Hilfiker-Kleiner, Denise, Preller, Matthias, Manstein, Dietmar J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920478/ https://www.ncbi.nlm.nih.gov/pubmed/24520162 http://dx.doi.org/10.7554/eLife.01603

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