Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report

One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the...

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Autores principales: Zarifian, Ahmadreza, Farhoodi, Zeinab, Amel, Roya, Mirzaee, Salmeh, Hassanzadeh-Nazarabadi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920508/
https://www.ncbi.nlm.nih.gov/pubmed/24551782
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author Zarifian, Ahmadreza
Farhoodi, Zeinab
Amel, Roya
Mirzaee, Salmeh
Hassanzadeh-Nazarabadi, Mohammad
author_facet Zarifian, Ahmadreza
Farhoodi, Zeinab
Amel, Roya
Mirzaee, Salmeh
Hassanzadeh-Nazarabadi, Mohammad
author_sort Zarifian, Ahmadreza
collection PubMed
description One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16; 6) (p12; q26) and 46, XY, t (16; 6) (p12; q26) in both partners, which induced such pregnancy complications. Chromosomal balanced translocation is one of the most common causes of recurrent spontaneous abortions (RSA). In such cases prenatal diagnosis (PND) during the 16(th) week of gestation is strongly recommended.
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spelling pubmed-39205082014-02-18 Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report Zarifian, Ahmadreza Farhoodi, Zeinab Amel, Roya Mirzaee, Salmeh Hassanzadeh-Nazarabadi, Mohammad Int J Mol Cell Med Case Report One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16; 6) (p12; q26) and 46, XY, t (16; 6) (p12; q26) in both partners, which induced such pregnancy complications. Chromosomal balanced translocation is one of the most common causes of recurrent spontaneous abortions (RSA). In such cases prenatal diagnosis (PND) during the 16(th) week of gestation is strongly recommended. Babol University of Medical Sciences 2012 /pmc/articles/PMC3920508/ /pubmed/24551782 Text en © 2012, International Journal of Molecular and Cellular Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zarifian, Ahmadreza
Farhoodi, Zeinab
Amel, Roya
Mirzaee, Salmeh
Hassanzadeh-Nazarabadi, Mohammad
Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report
title Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report
title_full Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report
title_fullStr Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report
title_full_unstemmed Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report
title_short Balanced Chromosomal Rearrangement in Recurrent Spontaneous Abortions: A Case Report
title_sort balanced chromosomal rearrangement in recurrent spontaneous abortions: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920508/
https://www.ncbi.nlm.nih.gov/pubmed/24551782
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