Cellular Response to Ionizing Radiation: A MicroRNA Story

MicroRNAs (miRNAs) represent a class of small non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They play a crucial role in diverse cellular pathways. Ionizing radiation (IR) is one of the most important treatment protocols for patients that suffer from cancer...

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Detalles Bibliográficos
Autores principales: Halimi, Mohammad, Asghari, S. Mohsen, Sariri, Reyhaneh, Moslemi, Dariush, Parsian, Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920513/
https://www.ncbi.nlm.nih.gov/pubmed/24551775
Descripción
Sumario:MicroRNAs (miRNAs) represent a class of small non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They play a crucial role in diverse cellular pathways. Ionizing radiation (IR) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. Recently it has been discovered that microRNA-mediated gene regulation interferes with radio-related pathways in ionizing radiation. Here, we review the recent discoveries about miRNAs in cellular response to IR. Thoroughly understanding the mechanism of miRNAs in radiation response, it will be possible to design new strategies for improving radiotherapy efficiency and ultimately cancer treatment.

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