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Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice
One of the applications of gold nanoparticles (GNPs) in medicine is radiation dose-enhancing effect. Although there are many simulations, in vitro and in vivo evidence that GNPs can enhance significantly the radiation dose effect of orthovoltage beams. These beams compared with megavoltage (MV) beam...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Babol University of Medical Sciences
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920534/ https://www.ncbi.nlm.nih.gov/pubmed/24551801 |
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author | Mousavie Anijdan, Sayyed Hossein Mahdavi, Seyyed Rabi Shirazi, Alireza Zarrinfard, Mohammad Ali Hajati, Jamshid |
author_facet | Mousavie Anijdan, Sayyed Hossein Mahdavi, Seyyed Rabi Shirazi, Alireza Zarrinfard, Mohammad Ali Hajati, Jamshid |
author_sort | Mousavie Anijdan, Sayyed Hossein |
collection | PubMed |
description | One of the applications of gold nanoparticles (GNPs) in medicine is radiation dose-enhancing effect. Although there are many simulations, in vitro and in vivo evidence that GNPs can enhance significantly the radiation dose effect of orthovoltage beams. These beams compared with megavoltage (MV) beams, have limited applications in radiotherapy. In order to evaluate GNPs radiosensitization performance with MV beams in-vivo, we used two most clinically used X-ray beams (6 and 18 MV) with the dose of 20 Gy for each mouse. Intratumoral injection of 50 nm GNPs with the concentration of 5 mg ml(-1) was applied to melanoma tumor growing in the left leg of 7 to 8 mice in 4 control and treatment groups of C57BL/6 mice. Albeit, using 10 cm plexiglass jig phantom in the beam path improved the radiation - treatments, the statistical differences between groups were not significant. According to the results, it is concluded that mice can be treated with smaller tumors and higher concentrations of GNPs in MV radiation beams. |
format | Online Article Text |
id | pubmed-3920534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-39205342014-02-18 Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice Mousavie Anijdan, Sayyed Hossein Mahdavi, Seyyed Rabi Shirazi, Alireza Zarrinfard, Mohammad Ali Hajati, Jamshid Int J Mol Cell Med Original Article One of the applications of gold nanoparticles (GNPs) in medicine is radiation dose-enhancing effect. Although there are many simulations, in vitro and in vivo evidence that GNPs can enhance significantly the radiation dose effect of orthovoltage beams. These beams compared with megavoltage (MV) beams, have limited applications in radiotherapy. In order to evaluate GNPs radiosensitization performance with MV beams in-vivo, we used two most clinically used X-ray beams (6 and 18 MV) with the dose of 20 Gy for each mouse. Intratumoral injection of 50 nm GNPs with the concentration of 5 mg ml(-1) was applied to melanoma tumor growing in the left leg of 7 to 8 mice in 4 control and treatment groups of C57BL/6 mice. Albeit, using 10 cm plexiglass jig phantom in the beam path improved the radiation - treatments, the statistical differences between groups were not significant. According to the results, it is concluded that mice can be treated with smaller tumors and higher concentrations of GNPs in MV radiation beams. Babol University of Medical Sciences 2013 /pmc/articles/PMC3920534/ /pubmed/24551801 Text en © 2013, International Journal of Molecular and Cellular Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mousavie Anijdan, Sayyed Hossein Mahdavi, Seyyed Rabi Shirazi, Alireza Zarrinfard, Mohammad Ali Hajati, Jamshid Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice |
title | Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice |
title_full | Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice |
title_fullStr | Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice |
title_full_unstemmed | Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice |
title_short | Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice |
title_sort | megavoltage x-ray dose enhancement with gold nanoparticles in tumor bearing mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920534/ https://www.ncbi.nlm.nih.gov/pubmed/24551801 |
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