Cargando…
The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification
Numerous studies indicate that γδ T cell receptor (γδTCR) expression alone does not reliably mark commitment of early thymic progenitors to the γδ fate. This raises the possibility that the γδTCR is unable to intrinsically specify fate and instead requires additional environmental factors, including...
Autores principales: | Coffey, Francis, Lee, Sang-Yun, Buus, Terkild B., Lauritsen, Jens-Peter Holst, Wong, Gladys W., Joachims, Michelle L., Thompson, Linda F., Zúñiga-Pflücker, Juan Carlos, Kappes, Dietmar J., Wiest, David L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920555/ https://www.ncbi.nlm.nih.gov/pubmed/24493796 http://dx.doi.org/10.1084/jem.20131540 |
Ejemplares similares
-
Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus
por: Buus, Terkild Brink, et al.
Publicado: (2017) -
Development of interleukin-17-producing Vγ2(+) γδ T cells is reduced by ICOS signaling in the thymus
por: Buus, Terkild Brink, et al.
Publicado: (2016) -
Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
por: Muro, Ryunosuke, et al.
Publicado: (2023) -
Integration of T‐cell receptor, Notch and cytokine signals programs mouse γδ T‐cell effector differentiation
por: Zarin, Payam, et al.
Publicado: (2018) -
γδ TCR T lymphoblastic leukemia in a child presenting with marked hyperleukocytosis
por: Mass, Jirong, et al.
Publicado: (2021)