Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

Type I interferons (IFN-1s) are antiviral cytokines that suppress blood production while paradoxically inducing hematopoietic stem cell (HSC) proliferation. Here, we clarify the relationship between the proliferative and suppressive effects of IFN-1s on HSC function during acute and chronic IFN-1 ex...

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Detalles Bibliográficos
Autores principales: Pietras, Eric M., Lakshminarasimhan, Ranjani, Techner, Jose-Marc, Fong, Sarah, Flach, Johanna, Binnewies, Mikhail, Passegué, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920566/
https://www.ncbi.nlm.nih.gov/pubmed/24493802
http://dx.doi.org/10.1084/jem.20131043

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