Necroptosis: Molecular Signalling and Translational Implications

Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also...

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Detalles Bibliográficos
Autores principales: Giampietri, Claudia, Starace, Donatella, Petrungaro, Simonetta, Filippini, Antonio, Ziparo, Elio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920604/
https://www.ncbi.nlm.nih.gov/pubmed/24587805
http://dx.doi.org/10.1155/2014/490275
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author Giampietri, Claudia
Starace, Donatella
Petrungaro, Simonetta
Filippini, Antonio
Ziparo, Elio
author_facet Giampietri, Claudia
Starace, Donatella
Petrungaro, Simonetta
Filippini, Antonio
Ziparo, Elio
author_sort Giampietri, Claudia
collection PubMed
description Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.
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spelling pubmed-39206042014-03-02 Necroptosis: Molecular Signalling and Translational Implications Giampietri, Claudia Starace, Donatella Petrungaro, Simonetta Filippini, Antonio Ziparo, Elio Int J Cell Biol Review Article Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis. Hindawi Publishing Corporation 2014 2014-01-23 /pmc/articles/PMC3920604/ /pubmed/24587805 http://dx.doi.org/10.1155/2014/490275 Text en Copyright © 2014 Claudia Giampietri et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Giampietri, Claudia
Starace, Donatella
Petrungaro, Simonetta
Filippini, Antonio
Ziparo, Elio
Necroptosis: Molecular Signalling and Translational Implications
title Necroptosis: Molecular Signalling and Translational Implications
title_full Necroptosis: Molecular Signalling and Translational Implications
title_fullStr Necroptosis: Molecular Signalling and Translational Implications
title_full_unstemmed Necroptosis: Molecular Signalling and Translational Implications
title_short Necroptosis: Molecular Signalling and Translational Implications
title_sort necroptosis: molecular signalling and translational implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920604/
https://www.ncbi.nlm.nih.gov/pubmed/24587805
http://dx.doi.org/10.1155/2014/490275
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AT filippiniantonio necroptosismolecularsignallingandtranslationalimplications
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