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Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI
Multiple sclerosis (MS) is an immune-mediated disease affecting central nervous system (CNS). Although MS is classically considered a white matter (WM) disease, the involvement of gray matter (GM) in the pathogenic process has been confirmed by pathology studies and MRI studies. Impairment of cognit...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920616/ https://www.ncbi.nlm.nih.gov/pubmed/24587905 http://dx.doi.org/10.1155/2014/609694 |
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author | Messina, Silvia Patti, Francesco |
author_facet | Messina, Silvia Patti, Francesco |
author_sort | Messina, Silvia |
collection | PubMed |
description | Multiple sclerosis (MS) is an immune-mediated disease affecting central nervous system (CNS). Although MS is classically considered a white matter (WM) disease, the involvement of gray matter (GM) in the pathogenic process has been confirmed by pathology studies and MRI studies. Impairment of cognitive domains such as memory, mental processing speed, attention, and executive function can occur from the early stage of the disease and tends to worsen over time, despite stable physical symptoms. WM demyelination is moderately correlated with CI, suggesting that probably WM abnormalities alone cannot fully explain the extent of clinical symptoms in MS, including CI. Several MRI techniques have shown the involvement of GM in MS and the association between GM damage, physical disability, and CI. The aim of this review is to provide an overview of CI and GM damage assessed by structural brain MRI. |
format | Online Article Text |
id | pubmed-3920616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39206162014-03-02 Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI Messina, Silvia Patti, Francesco Mult Scler Int Review Article Multiple sclerosis (MS) is an immune-mediated disease affecting central nervous system (CNS). Although MS is classically considered a white matter (WM) disease, the involvement of gray matter (GM) in the pathogenic process has been confirmed by pathology studies and MRI studies. Impairment of cognitive domains such as memory, mental processing speed, attention, and executive function can occur from the early stage of the disease and tends to worsen over time, despite stable physical symptoms. WM demyelination is moderately correlated with CI, suggesting that probably WM abnormalities alone cannot fully explain the extent of clinical symptoms in MS, including CI. Several MRI techniques have shown the involvement of GM in MS and the association between GM damage, physical disability, and CI. The aim of this review is to provide an overview of CI and GM damage assessed by structural brain MRI. Hindawi Publishing Corporation 2014 2014-01-22 /pmc/articles/PMC3920616/ /pubmed/24587905 http://dx.doi.org/10.1155/2014/609694 Text en Copyright © 2014 S. Messina and F. Patti. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Messina, Silvia Patti, Francesco Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI |
title | Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI |
title_full | Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI |
title_fullStr | Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI |
title_full_unstemmed | Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI |
title_short | Gray Matters in Multiple Sclerosis: Cognitive Impairment and Structural MRI |
title_sort | gray matters in multiple sclerosis: cognitive impairment and structural mri |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920616/ https://www.ncbi.nlm.nih.gov/pubmed/24587905 http://dx.doi.org/10.1155/2014/609694 |
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