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Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study

Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic fac...

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Detalles Bibliográficos
Autores principales: Anuradha, A., Kiran Kumar Naik, B., Vijay Srinivas, G., Devi, Ramisetty Sabitha, Puneet, H. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920617/
https://www.ncbi.nlm.nih.gov/pubmed/24587802
http://dx.doi.org/10.1155/2014/614291
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author Anuradha, A.
Kiran Kumar Naik, B.
Vijay Srinivas, G.
Devi, Ramisetty Sabitha
Puneet, H. K.
author_facet Anuradha, A.
Kiran Kumar Naik, B.
Vijay Srinivas, G.
Devi, Ramisetty Sabitha
Puneet, H. K.
author_sort Anuradha, A.
collection PubMed
description Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression.
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spelling pubmed-39206172014-03-02 Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study Anuradha, A. Kiran Kumar Naik, B. Vijay Srinivas, G. Devi, Ramisetty Sabitha Puneet, H. K. J Oncol Research Article Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression. Hindawi Publishing Corporation 2014 2014-01-23 /pmc/articles/PMC3920617/ /pubmed/24587802 http://dx.doi.org/10.1155/2014/614291 Text en Copyright © 2014 A. Anuradha et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Anuradha, A.
Kiran Kumar Naik, B.
Vijay Srinivas, G.
Devi, Ramisetty Sabitha
Puneet, H. K.
Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study
title Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study
title_full Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study
title_fullStr Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study
title_full_unstemmed Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study
title_short Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study
title_sort incidence of mast cells in oral squamous cell carcinoma: a short study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920617/
https://www.ncbi.nlm.nih.gov/pubmed/24587802
http://dx.doi.org/10.1155/2014/614291
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