Cargando…
Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study
Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic fac...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920617/ https://www.ncbi.nlm.nih.gov/pubmed/24587802 http://dx.doi.org/10.1155/2014/614291 |
_version_ | 1782303199862980608 |
---|---|
author | Anuradha, A. Kiran Kumar Naik, B. Vijay Srinivas, G. Devi, Ramisetty Sabitha Puneet, H. K. |
author_facet | Anuradha, A. Kiran Kumar Naik, B. Vijay Srinivas, G. Devi, Ramisetty Sabitha Puneet, H. K. |
author_sort | Anuradha, A. |
collection | PubMed |
description | Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression. |
format | Online Article Text |
id | pubmed-3920617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39206172014-03-02 Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study Anuradha, A. Kiran Kumar Naik, B. Vijay Srinivas, G. Devi, Ramisetty Sabitha Puneet, H. K. J Oncol Research Article Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression. Hindawi Publishing Corporation 2014 2014-01-23 /pmc/articles/PMC3920617/ /pubmed/24587802 http://dx.doi.org/10.1155/2014/614291 Text en Copyright © 2014 A. Anuradha et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Anuradha, A. Kiran Kumar Naik, B. Vijay Srinivas, G. Devi, Ramisetty Sabitha Puneet, H. K. Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study |
title | Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study |
title_full | Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study |
title_fullStr | Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study |
title_full_unstemmed | Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study |
title_short | Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study |
title_sort | incidence of mast cells in oral squamous cell carcinoma: a short study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920617/ https://www.ncbi.nlm.nih.gov/pubmed/24587802 http://dx.doi.org/10.1155/2014/614291 |
work_keys_str_mv | AT anuradhaa incidenceofmastcellsinoralsquamouscellcarcinomaashortstudy AT kirankumarnaikb incidenceofmastcellsinoralsquamouscellcarcinomaashortstudy AT vijaysrinivasg incidenceofmastcellsinoralsquamouscellcarcinomaashortstudy AT deviramisettysabitha incidenceofmastcellsinoralsquamouscellcarcinomaashortstudy AT puneethk incidenceofmastcellsinoralsquamouscellcarcinomaashortstudy |