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A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)

Radioiodinated meta-iodobenzylguanidine (MIBG) is one of the important radiopharmaceuticals in Nuclear Medicine. [(123/131)I] MIBG is used for imaging of Adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. For clinical application, radioiodinated MIBG...

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Autores principales: Sheikholislam, Zahra, Soleimani, Zohreh, Moghimi, Abolghasem, Shahhosseini, Soraya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920697/
https://www.ncbi.nlm.nih.gov/pubmed/24523752
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author Sheikholislam, Zahra
Soleimani, Zohreh
Moghimi, Abolghasem
Shahhosseini, Soraya
author_facet Sheikholislam, Zahra
Soleimani, Zohreh
Moghimi, Abolghasem
Shahhosseini, Soraya
author_sort Sheikholislam, Zahra
collection PubMed
description Radioiodinated meta-iodobenzylguanidine (MIBG) is one of the important radiopharmaceuticals in Nuclear Medicine. [(123/131)I] MIBG is used for imaging of Adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. For clinical application, radioiodinated MIBG is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a nucleophilic substitution reaction with cold iodine ((127)I). The unlabelled MIBG hemisulfate is synthesized by the procedure described by Wieland et al. (1980). The availability of a more practical and cost-effective procedure for MIBG preparation encouraged us to study the MIBG synthesis methods. In this study the preparation of MIBG through different methods were evaluated and a new method, which is one step, simple and cost-effective is introduced. The method has ability to be scaled up for production of unlabelled MIBG.
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spelling pubmed-39206972014-02-12 A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG) Sheikholislam, Zahra Soleimani, Zohreh Moghimi, Abolghasem Shahhosseini, Soraya Iran J Pharm Res Original Article Radioiodinated meta-iodobenzylguanidine (MIBG) is one of the important radiopharmaceuticals in Nuclear Medicine. [(123/131)I] MIBG is used for imaging of Adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. For clinical application, radioiodinated MIBG is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a nucleophilic substitution reaction with cold iodine ((127)I). The unlabelled MIBG hemisulfate is synthesized by the procedure described by Wieland et al. (1980). The availability of a more practical and cost-effective procedure for MIBG preparation encouraged us to study the MIBG synthesis methods. In this study the preparation of MIBG through different methods were evaluated and a new method, which is one step, simple and cost-effective is introduced. The method has ability to be scaled up for production of unlabelled MIBG. Shaheed Beheshti University of Medical Sciences 2013 /pmc/articles/PMC3920697/ /pubmed/24523752 Text en © 2013 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sheikholislam, Zahra
Soleimani, Zohreh
Moghimi, Abolghasem
Shahhosseini, Soraya
A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)
title A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)
title_full A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)
title_fullStr A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)
title_full_unstemmed A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)
title_short A convenient Simple Method for Synthesis of Meta-iodobenzylguanidine (MIBG)
title_sort convenient simple method for synthesis of meta-iodobenzylguanidine (mibg)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920697/
https://www.ncbi.nlm.nih.gov/pubmed/24523752
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