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Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives
The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920700/ https://www.ncbi.nlm.nih.gov/pubmed/24523751 |
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author | Nassiri Koopaei, Mansur Assarzadeh, Mohammad Javad Almasirad, Ali Ghasemi-Niri, Seyedeh Farnaz Amini, Mohsen Kebriaeezadeh, Abbas Nassiri Koopaei, Nasser Ghadimi, Maryam Tabei, Arash |
author_facet | Nassiri Koopaei, Mansur Assarzadeh, Mohammad Javad Almasirad, Ali Ghasemi-Niri, Seyedeh Farnaz Amini, Mohsen Kebriaeezadeh, Abbas Nassiri Koopaei, Nasser Ghadimi, Maryam Tabei, Arash |
author_sort | Nassiri Koopaei, Mansur |
collection | PubMed |
description | The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds 10a-10e and 15a-15d were prepared by condensation of corresponding hydrazides 7,8 and 11-14 with different aldehydes 9a-9e. The structures of all synthesized compounds were confirmed by means of FT-IR, 1H-NMR and Mass spectra. All compounds were evaluated for their analgesic activities by abdominal constriction test (writhing test). Most of the synthesized compounds induced significant reduction in the writhing response when compared to control and compound 15 was more potent than mefenamic acid in the writhing test. |
format | Online Article Text |
id | pubmed-3920700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-39207002014-02-12 Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives Nassiri Koopaei, Mansur Assarzadeh, Mohammad Javad Almasirad, Ali Ghasemi-Niri, Seyedeh Farnaz Amini, Mohsen Kebriaeezadeh, Abbas Nassiri Koopaei, Nasser Ghadimi, Maryam Tabei, Arash Iran J Pharm Res Original Article The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds 10a-10e and 15a-15d were prepared by condensation of corresponding hydrazides 7,8 and 11-14 with different aldehydes 9a-9e. The structures of all synthesized compounds were confirmed by means of FT-IR, 1H-NMR and Mass spectra. All compounds were evaluated for their analgesic activities by abdominal constriction test (writhing test). Most of the synthesized compounds induced significant reduction in the writhing response when compared to control and compound 15 was more potent than mefenamic acid in the writhing test. Shaheed Beheshti University of Medical Sciences 2013 /pmc/articles/PMC3920700/ /pubmed/24523751 Text en © 2013 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nassiri Koopaei, Mansur Assarzadeh, Mohammad Javad Almasirad, Ali Ghasemi-Niri, Seyedeh Farnaz Amini, Mohsen Kebriaeezadeh, Abbas Nassiri Koopaei, Nasser Ghadimi, Maryam Tabei, Arash Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives |
title | Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives |
title_full | Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives |
title_fullStr | Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives |
title_full_unstemmed | Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives |
title_short | Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives |
title_sort | synthesis and analgesic activity of novel hydrazide and hydrazine derivatives |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920700/ https://www.ncbi.nlm.nih.gov/pubmed/24523751 |
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