Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities

In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricula...

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Autores principales: Mokni, Meherzia, Hamlaoui, Sonia, Karkouch, Ines, Amri, Mohamed, Marzouki, Lamjed, Limam, Ferid, Aouani, Ezzedine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920701/
https://www.ncbi.nlm.nih.gov/pubmed/24523766
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author Mokni, Meherzia
Hamlaoui, Sonia
Karkouch, Ines
Amri, Mohamed
Marzouki, Lamjed
Limam, Ferid
Aouani, Ezzedine
author_facet Mokni, Meherzia
Hamlaoui, Sonia
Karkouch, Ines
Amri, Mohamed
Marzouki, Lamjed
Limam, Ferid
Aouani, Ezzedine
author_sort Mokni, Meherzia
collection PubMed
description In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were determined. Data showed that resveratrol improved recovery of post-ischemic ventricular functions when compared to control. Resveratrol also improved myocardial lipoperoxidation, free iron and antioxidant enzyme activities. Resveratrol decreased significantly catalase while it increased peroxidase and superoxide dismutase activities. In this later case, native PAGE analysis of superoxide dismutase isoforms revealed that resveratrol up regulated iron and manganese isoforms. Resveratrol exerted potential cardioprotection partly by its antioxidant properties.
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spelling pubmed-39207012014-02-12 Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities Mokni, Meherzia Hamlaoui, Sonia Karkouch, Ines Amri, Mohamed Marzouki, Lamjed Limam, Ferid Aouani, Ezzedine Iran J Pharm Res Original Article In this study, we investigated the cardioprotective effects of resveratrol. Rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. Isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were determined. Data showed that resveratrol improved recovery of post-ischemic ventricular functions when compared to control. Resveratrol also improved myocardial lipoperoxidation, free iron and antioxidant enzyme activities. Resveratrol decreased significantly catalase while it increased peroxidase and superoxide dismutase activities. In this later case, native PAGE analysis of superoxide dismutase isoforms revealed that resveratrol up regulated iron and manganese isoforms. Resveratrol exerted potential cardioprotection partly by its antioxidant properties. Shaheed Beheshti University of Medical Sciences 2013 /pmc/articles/PMC3920701/ /pubmed/24523766 Text en © 2013 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mokni, Meherzia
Hamlaoui, Sonia
Karkouch, Ines
Amri, Mohamed
Marzouki, Lamjed
Limam, Ferid
Aouani, Ezzedine
Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities
title Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities
title_full Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities
title_fullStr Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities
title_full_unstemmed Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities
title_short Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities
title_sort resveratrol provides cardioprotection after ischemia/reperfusion injury via modulation of antioxidant enzyme activities
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920701/
https://www.ncbi.nlm.nih.gov/pubmed/24523766
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