Cargando…
Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System
Viruses attempt to create a distinctive cellular environment to favor viral replication and spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections. While sphingolipids such as sphingomyelin and ceramide were reported to influence th...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920843/ https://www.ncbi.nlm.nih.gov/pubmed/24672735 http://dx.doi.org/10.1155/2014/793815 |
_version_ | 1782303235565944832 |
---|---|
author | Vijayan, Madhuvanthi Hahm, Bumsuk |
author_facet | Vijayan, Madhuvanthi Hahm, Bumsuk |
author_sort | Vijayan, Madhuvanthi |
collection | PubMed |
description | Viruses attempt to create a distinctive cellular environment to favor viral replication and spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections. While sphingolipids such as sphingomyelin and ceramide were reported to influence the entry step of several viruses, sphingolipid-metabolizing enzymes could directly alter viral replication processes. Influenza virus was shown to increase the level of sphingosine kinase (SK) 1 to promote virus propagation. The mechanism involves regulation of intracellular signaling pathways, leading to the amplification of influenza viral RNA synthesis and nuclear export of viral ribonucleoprotein (RNP) complex. However, bovine viral diarrhea virus inhibits SK1 to enhance the efficacy of virus replication, demonstrating the presence of virus-specific strategies for modulation of the sphingolipid system. Therefore, investigating the sphingolipid metabolism and signaling in the context of virus replication could help us design innovative therapeutic approaches to improve human health. |
format | Online Article Text |
id | pubmed-3920843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39208432014-03-26 Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System Vijayan, Madhuvanthi Hahm, Bumsuk Scientifica (Cairo) Review Article Viruses attempt to create a distinctive cellular environment to favor viral replication and spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections. While sphingolipids such as sphingomyelin and ceramide were reported to influence the entry step of several viruses, sphingolipid-metabolizing enzymes could directly alter viral replication processes. Influenza virus was shown to increase the level of sphingosine kinase (SK) 1 to promote virus propagation. The mechanism involves regulation of intracellular signaling pathways, leading to the amplification of influenza viral RNA synthesis and nuclear export of viral ribonucleoprotein (RNP) complex. However, bovine viral diarrhea virus inhibits SK1 to enhance the efficacy of virus replication, demonstrating the presence of virus-specific strategies for modulation of the sphingolipid system. Therefore, investigating the sphingolipid metabolism and signaling in the context of virus replication could help us design innovative therapeutic approaches to improve human health. Hindawi Publishing Corporation 2014 2014-01-23 /pmc/articles/PMC3920843/ /pubmed/24672735 http://dx.doi.org/10.1155/2014/793815 Text en Copyright © 2014 M. Vijayan and B. Hahm. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Vijayan, Madhuvanthi Hahm, Bumsuk Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System |
title | Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System |
title_full | Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System |
title_fullStr | Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System |
title_full_unstemmed | Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System |
title_short | Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System |
title_sort | influenza viral manipulation of sphingolipid metabolism and signaling to modulate host defense system |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920843/ https://www.ncbi.nlm.nih.gov/pubmed/24672735 http://dx.doi.org/10.1155/2014/793815 |
work_keys_str_mv | AT vijayanmadhuvanthi influenzaviralmanipulationofsphingolipidmetabolismandsignalingtomodulatehostdefensesystem AT hahmbumsuk influenzaviralmanipulationofsphingolipidmetabolismandsignalingtomodulatehostdefensesystem |