Cargando…

Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System

Viruses attempt to create a distinctive cellular environment to favor viral replication and spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections. While sphingolipids such as sphingomyelin and ceramide were reported to influence th...

Descripción completa

Detalles Bibliográficos
Autores principales: Vijayan, Madhuvanthi, Hahm, Bumsuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920843/
https://www.ncbi.nlm.nih.gov/pubmed/24672735
http://dx.doi.org/10.1155/2014/793815
_version_ 1782303235565944832
author Vijayan, Madhuvanthi
Hahm, Bumsuk
author_facet Vijayan, Madhuvanthi
Hahm, Bumsuk
author_sort Vijayan, Madhuvanthi
collection PubMed
description Viruses attempt to create a distinctive cellular environment to favor viral replication and spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections. While sphingolipids such as sphingomyelin and ceramide were reported to influence the entry step of several viruses, sphingolipid-metabolizing enzymes could directly alter viral replication processes. Influenza virus was shown to increase the level of sphingosine kinase (SK) 1 to promote virus propagation. The mechanism involves regulation of intracellular signaling pathways, leading to the amplification of influenza viral RNA synthesis and nuclear export of viral ribonucleoprotein (RNP) complex. However, bovine viral diarrhea virus inhibits SK1 to enhance the efficacy of virus replication, demonstrating the presence of virus-specific strategies for modulation of the sphingolipid system. Therefore, investigating the sphingolipid metabolism and signaling in the context of virus replication could help us design innovative therapeutic approaches to improve human health.
format Online
Article
Text
id pubmed-3920843
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-39208432014-03-26 Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System Vijayan, Madhuvanthi Hahm, Bumsuk Scientifica (Cairo) Review Article Viruses attempt to create a distinctive cellular environment to favor viral replication and spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections. While sphingolipids such as sphingomyelin and ceramide were reported to influence the entry step of several viruses, sphingolipid-metabolizing enzymes could directly alter viral replication processes. Influenza virus was shown to increase the level of sphingosine kinase (SK) 1 to promote virus propagation. The mechanism involves regulation of intracellular signaling pathways, leading to the amplification of influenza viral RNA synthesis and nuclear export of viral ribonucleoprotein (RNP) complex. However, bovine viral diarrhea virus inhibits SK1 to enhance the efficacy of virus replication, demonstrating the presence of virus-specific strategies for modulation of the sphingolipid system. Therefore, investigating the sphingolipid metabolism and signaling in the context of virus replication could help us design innovative therapeutic approaches to improve human health. Hindawi Publishing Corporation 2014 2014-01-23 /pmc/articles/PMC3920843/ /pubmed/24672735 http://dx.doi.org/10.1155/2014/793815 Text en Copyright © 2014 M. Vijayan and B. Hahm. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vijayan, Madhuvanthi
Hahm, Bumsuk
Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System
title Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System
title_full Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System
title_fullStr Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System
title_full_unstemmed Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System
title_short Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System
title_sort influenza viral manipulation of sphingolipid metabolism and signaling to modulate host defense system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920843/
https://www.ncbi.nlm.nih.gov/pubmed/24672735
http://dx.doi.org/10.1155/2014/793815
work_keys_str_mv AT vijayanmadhuvanthi influenzaviralmanipulationofsphingolipidmetabolismandsignalingtomodulatehostdefensesystem
AT hahmbumsuk influenzaviralmanipulationofsphingolipidmetabolismandsignalingtomodulatehostdefensesystem