The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21(WAF1/CIP1)

The p90 ribosomal S6 kinase (RSK) family is a group of highly conserved Ser/Thr kinases that promote cell proliferation, growth, motility and survival. As they are almost exclusively activated downstream of extracellular signal-regulated kinases 1 and 2 (ERK1/2), therapeutic intervention by RSK inhi...

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Detalles Bibliográficos
Autores principales: Neise, D, Sohn, D, Stefanski, A, Goto, H, Inagaki, M, Wesselborg, S, Budach, W, Stühler, K, Jänicke, R U
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920941/
https://www.ncbi.nlm.nih.gov/pubmed/24136223
http://dx.doi.org/10.1038/cddis.2013.386

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