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Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction of the synthesized serine is routed to a pathway for ATP production. The pathway is composed by reactions from serine synthesis, one-carbon...
Autores principales: | Tedeschi, P M, Markert, E K, Gounder, M, Lin, H, Dvorzhinski, D, Dolfi, S C, Chan, L L-Y, Qiu, J, DiPaola, R S, Hirshfield, K M, Boros, L G, Bertino, J R, Oltvai, Z N, Vazquez, A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920946/ https://www.ncbi.nlm.nih.gov/pubmed/24157871 http://dx.doi.org/10.1038/cddis.2013.393 |
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