The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG

The cannabinoid CB(2) receptor, which is activated by the endocannabinoid 2-arachidonoyl-glycerol (2-AG), protects striatal neurons from apoptotic death caused by the local administration of malonate, a rat model of Huntington's disease (HD). In the present study, we investigated whether endoca...

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Detalles Bibliográficos
Autores principales: Valdeolivas, S, Pazos, M R, Bisogno, T, Piscitelli, F, Iannotti, F A, Allarà, M, Sagredo, O, Di Marzo, V, Fernández-Ruiz, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920947/
https://www.ncbi.nlm.nih.gov/pubmed/24136226
http://dx.doi.org/10.1038/cddis.2013.387

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