Cargando…

killerFLIP: a novel lytic peptide specifically inducing cancer cell death

One of the objectives in the development of effective cancer therapy is induction of tumor-selective cell death. Toward this end, we have identified a small peptide that, when introduced into cells via a TAT cell-delivery system, shows a remarkably potent cytoxicity in a variety of cancer cell lines...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pennarun, B, Gaidos, G, Bucur, O, Tinari, A, Rupasinghe, C, Jin, T, Dewar, R, Song, K, Santos, M T, Malorni, W, Mierke, D, Khosravi-Far, R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920952/ https://www.ncbi.nlm.nih.gov/pubmed/24176852 http://dx.doi.org/10.1038/cddis.2013.401

Ejemplares similares

A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death
por: Bucur, Octavian, et al.
Publicado: (2015)

Identification and Characterization of the Interaction Site between cFLIP(L) and Calmodulin
por: Gaidos, Gabriel, et al.
Publicado: (2015)

Combination of Bortezomib and Mitotic Inhibitors Down-Modulate Bcr-Abl and Efficiently Eliminates Tyrosine-Kinase Inhibitor Sensitive and Resistant Bcr-Abl-Positive Leukemic Cells
por: Bucur, Octavian, et al.
Publicado: (2013)

Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications
por: Bucur, O, et al.
Publicado: (2012)

Activation of Cyclin-Dependent Kinase 5 Is a Consequence of Cell Death
por: Ye, Yixia, et al.
Publicado: (2009)

Detection of trans–cis flips and peptide-plane flips in protein structures
por: Touw, Wouter G., et al.
Publicado: (2015)

The septin cytoskeleton regulates natural killer cell lytic granule release
por: Phatarpekar, Prasad V., et al.
Publicado: (2020)

Efficient recruitment of c‐FLIP(L) to the death‐inducing signaling complex leads to Fas resistance in natural killer‐cell lymphoma
por: Masuda, Azuchi, et al.
Publicado: (2020)

Two modes of lytic granule fusion during degranulation by natural killer cells
por: Liu, Dongfang, et al.
Publicado: (2011)

Dynamics of mitochondrial raft-like microdomains in cell life and death
por: Sorice, Maurizio, et al.
Publicado: (2012)

Dual channel STED nanoscopy of lytic granules on actin filaments in natural killer cells
por: Mace, Emily M., et al.
Publicado: (2012)

Locked and Loaded: Mechanisms Regulating Natural Killer Cell Lytic Granule Biogenesis and Release
por: Ham, Hyoungjun, et al.
Publicado: (2022)

Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways
por: Gunda, V, et al.
Publicado: (2014)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

The Quantitative-Phase Dynamics of Apoptosis and Lytic Cell Death
por: Vicar, Tomas, et al.
Publicado: (2020)

Rapid Lytic Granule Convergence to the MTOC in Natural Killer Cells Is Dependent on Dynein But Not Cytolytic Commitment
por: Mentlik, Ashley N., et al.
Publicado: (2010)

Natural killer lytic-associated molecule plays a role in controlling tumor dissemination and metastasis
por: Hoover, Richard G., et al.
Publicado: (2012)

Flipping the dogma – phosphatidylserine in non-apoptotic cell death
por: Shlomovitz, Inbar, et al.
Publicado: (2019)

A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7
por: Hopkins, Barbara L., et al.
Publicado: (2018)

SU(5): to flip or not to flip
por: Nanopoulos, Dimitri V
Publicado: (1988)

The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments
Publicado: (1990)

Extracellular histones aggravate autoimmune arthritis by lytic cell death
por: Jung, Jaeyong, et al.
Publicado: (2022)

Lytic Cell Death in Specific Microglial Subsets Is Required for Preventing Atypical Behavior in Mice
por: Chuang, Hsiu-Chun, et al.
Publicado: (2021)

Identification of a novel lytic peptide for the treatment of solid tumours
por: Szczepanski, Claudia, et al.
Publicado: (2014)

Isolation of a Peptide That Binds to Pseudomonas aeruginosa Lytic Bacteriophage
por: Chan, Soo Khim, et al.
Publicado: (2022)

A Cell Permeable Peptide Targeting the Intracellular Loop 2 of Endothelin B Receptor Reduces Pulmonary Hypertension in a Hypoxic Rat Model
por: Green, Daniel S., et al.
Publicado: (2013)

Flipping the flipped: the co-creational classroom
por: Uskoković, Vuk
Publicado: (2018)

An actin cytoskeletal barrier inhibits lytic granule release from natural killer cells in patients with Chediak-Higashi syndrome
por: Gil-Krzewska, Aleksandra, et al.
Publicado: (2018)

KSHV RTA Abolishes NFκB Responsive Gene Expression during Lytic Reactivation by Targeting vFLIP for Degradation via the Proteasome
por: Ehrlich, Elana S., et al.
Publicado: (2014)

Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death
por: Kroken, Abby R., et al.
Publicado: (2022)

Modeling of the Ebola Virus Delta Peptide Reveals a Potential Lytic Sequence Motif
por: Gallaher, William R., et al.
Publicado: (2015)

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse
por: Rak, Gregory D., et al.
Publicado: (2011)

Fas ligand and lytic granule differentially control cytotoxic dynamics of natural killer cell against cancer target
por: Zhu, Yanting, et al.
Publicado: (2016)

Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity
por: Lawrence, Donald W., et al.
Publicado: (2020)

Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death
por: Zhang, Yan, et al.
Publicado: (2022)

The development of activatable lytic peptides for targeting triple negative breast cancer
por: Zhao, Hui, et al.
Publicado: (2017)

Fungi Infecting Plants and Animals: Killers, Non-Killers, and Cell Death
por: Sharon, Amir, et al.
Publicado: (2013)

Flipped Cryptons and the UHECRs
por: Ellis, John R., et al.
Publicado: (2004)

Flipped classroom questions
por: Afrashtehfar, K. I., et al.
Publicado: (2022)

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell–mediated cytotoxicity
por: Tuli, Amit, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_aaie9ugf9aeqha6ndue5tae70c