Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer

Triple-negative breast cancers (TNBCs) are clinically aggressive forms associated with a poor prognosis. We evaluated the cytotoxic effect exerted on triple-negative MDA-MB231 breast cancer cells both by parthenolide and its soluble analogue dimethylamino parthenolide (DMAPT) and explored the underl...

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Detalles Bibliográficos
Autores principales: D'Anneo, A, Carlisi, D, Lauricella, M, Puleio, R, Martinez, R, Di Bella, S, Di Marco, P, Emanuele, S, Di Fiore, R, Guercio, A, Vento, R, Tesoriere, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920954/
https://www.ncbi.nlm.nih.gov/pubmed/24176849
http://dx.doi.org/10.1038/cddis.2013.415

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