Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants

Autophagy is a critical regulator of organellar homeostasis, particularly of mitochondria. Upon the loss of membrane potential, dysfunctional mitochondria are selectively removed by autophagy through recruitment of the E3 ligase Parkin by the PTEN-induced kinase 1 (PINK1) and subsequent ubiquitinati...

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Detalles Bibliográficos
Autores principales: de Castro, I P, Costa, A C, Celardo, I, Tufi, R, Dinsdale, D, Loh, S H Y, Martins, L M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920958/
https://www.ncbi.nlm.nih.gov/pubmed/24157867
http://dx.doi.org/10.1038/cddis.2013.394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920958/
https://www.ncbi.nlm.nih.gov/pubmed/24157867
http://dx.doi.org/10.1038/cddis.2013.394

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