Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface

The biological functions of myotonic dystrophy protein kinase (DMPK), a serine/threonine kinase whose gene mutations cause myotonic dystrophy type 1 (DM1), remain poorly understood. Several DMPK isoforms exist, and the long ones (DMPK-A/B/C/D) are associated with the mitochondria, where they exert u...

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Detalles Bibliográficos
Autores principales: Pantic, B, Trevisan, E, Citta, A, Rigobello, M P, Marin, O, Bernardi, P, Salvatori, S, Rasola, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920960/
https://www.ncbi.nlm.nih.gov/pubmed/24136222
http://dx.doi.org/10.1038/cddis.2013.385

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