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The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma

Objectives. The aim of this study was to investigate the association of RCC and Ala16Val polymorphism in Turkish patients with RCC. Materials and Methods. A total of 41 patients with RCC who underwent radical or partial nephrectomy in our clinic and 50 healthy volunteers living in the same geographi...

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Autores principales: Atilgan, Dogan, Parlaktas, Bekir S., Uluocak, Nihat, Kolukcu, Engin, Erdemir, Fikret, Ozyurt, Huseyin, Erkorkmaz, Unal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920972/
https://www.ncbi.nlm.nih.gov/pubmed/24587799
http://dx.doi.org/10.1155/2014/932481
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author Atilgan, Dogan
Parlaktas, Bekir S.
Uluocak, Nihat
Kolukcu, Engin
Erdemir, Fikret
Ozyurt, Huseyin
Erkorkmaz, Unal
author_facet Atilgan, Dogan
Parlaktas, Bekir S.
Uluocak, Nihat
Kolukcu, Engin
Erdemir, Fikret
Ozyurt, Huseyin
Erkorkmaz, Unal
author_sort Atilgan, Dogan
collection PubMed
description Objectives. The aim of this study was to investigate the association of RCC and Ala16Val polymorphism in Turkish patients with RCC. Materials and Methods. A total of 41 patients with RCC who underwent radical or partial nephrectomy in our clinic and 50 healthy volunteers living in the same geographic area were included in this study. DNA samples from serum of RCC patients and controls were genotyped for MnSOD polymorphism analysis. Genotype ratios and allele frequencies were compared between two groups and odd ratios with 95% confidence intervals were calculated statistically. A P value of <0.05 was considered statistically significant. Results. There was a significant difference in the MnSOD genotype distributions between the RCC patients and the controls in terms of Ala/Ala+Ala/Val and Val/Val genotypes (P = 0.039). The Ala/Ala+Ala/Val genotypes were found significantly suspicious for RCC with an OR of 2.64 (95% CI = 1.06–6.69, P = 0.039). In addition, Ala allele was found significantly suspicious for RCC with an OR of 2.26 (95% CI = 1.24–4.12, P = 0.009). Conclusion. Our study indicated that MnSOD Ala16Val polymorphism may be one of the many genetic factors for renal cancer susceptibility in Turkish patients.
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spelling pubmed-39209722014-03-02 The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma Atilgan, Dogan Parlaktas, Bekir S. Uluocak, Nihat Kolukcu, Engin Erdemir, Fikret Ozyurt, Huseyin Erkorkmaz, Unal Adv Urol Research Article Objectives. The aim of this study was to investigate the association of RCC and Ala16Val polymorphism in Turkish patients with RCC. Materials and Methods. A total of 41 patients with RCC who underwent radical or partial nephrectomy in our clinic and 50 healthy volunteers living in the same geographic area were included in this study. DNA samples from serum of RCC patients and controls were genotyped for MnSOD polymorphism analysis. Genotype ratios and allele frequencies were compared between two groups and odd ratios with 95% confidence intervals were calculated statistically. A P value of <0.05 was considered statistically significant. Results. There was a significant difference in the MnSOD genotype distributions between the RCC patients and the controls in terms of Ala/Ala+Ala/Val and Val/Val genotypes (P = 0.039). The Ala/Ala+Ala/Val genotypes were found significantly suspicious for RCC with an OR of 2.64 (95% CI = 1.06–6.69, P = 0.039). In addition, Ala allele was found significantly suspicious for RCC with an OR of 2.26 (95% CI = 1.24–4.12, P = 0.009). Conclusion. Our study indicated that MnSOD Ala16Val polymorphism may be one of the many genetic factors for renal cancer susceptibility in Turkish patients. Hindawi Publishing Corporation 2014 2014-01-23 /pmc/articles/PMC3920972/ /pubmed/24587799 http://dx.doi.org/10.1155/2014/932481 Text en Copyright © 2014 Dogan Atilgan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Atilgan, Dogan
Parlaktas, Bekir S.
Uluocak, Nihat
Kolukcu, Engin
Erdemir, Fikret
Ozyurt, Huseyin
Erkorkmaz, Unal
The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma
title The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma
title_full The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma
title_fullStr The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma
title_full_unstemmed The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma
title_short The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma
title_sort relationship between ala16val single gene polymorphism and renal cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920972/
https://www.ncbi.nlm.nih.gov/pubmed/24587799
http://dx.doi.org/10.1155/2014/932481
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