Cargando…
Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period
Aims. To study the etiology, diagnostic features, and clinical significance of myelonecrosis. Methods. A retrospective review of all trephine biopsies done over 12 years (January 2000 to December 2012) in Department of pathology was done and all trephine biopsies showing MN were identified and studi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920973/ https://www.ncbi.nlm.nih.gov/pubmed/24587907 http://dx.doi.org/10.1155/2014/890510 |
_version_ | 1782303254006202368 |
---|---|
author | Rekha, Jinkala Sree Kar, Rakhee Basu, Debdatta |
author_facet | Rekha, Jinkala Sree Kar, Rakhee Basu, Debdatta |
author_sort | Rekha, Jinkala Sree |
collection | PubMed |
description | Aims. To study the etiology, diagnostic features, and clinical significance of myelonecrosis. Methods. A retrospective review of all trephine biopsies done over 12 years (January 2000 to December 2012) in Department of pathology was done and all trephine biopsies showing MN were identified and studied. Results. Twenty-five cases accounting for 0.4% were identified. Fever and generalized weakness were the common presenting symptoms. Anemia was seen in all cases followed by thrombocytopaenia. Malignancy was the underlying cause in 64% of cases; hematolymphoid malignancy was seen in two-thirds and solid malignancies in one-third of the cases. Tuberculosis accounted for 16% of the cases and the etiology was unknown in 12%. Conclusions. The causes of MN are varied and hematological malignancy and solid malignancies are the most common causes. Presence of myelonecrosis is associated with a poor prognosis. Myelonecrosis may obscure the underlying disorder and hence a thorough search in the bone marrow biopsy itself with the help of immunohistochemistry may prove worthwhile in identifying the underlying disease. |
format | Online Article Text |
id | pubmed-3920973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39209732014-03-02 Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period Rekha, Jinkala Sree Kar, Rakhee Basu, Debdatta Bone Marrow Res Clinical Study Aims. To study the etiology, diagnostic features, and clinical significance of myelonecrosis. Methods. A retrospective review of all trephine biopsies done over 12 years (January 2000 to December 2012) in Department of pathology was done and all trephine biopsies showing MN were identified and studied. Results. Twenty-five cases accounting for 0.4% were identified. Fever and generalized weakness were the common presenting symptoms. Anemia was seen in all cases followed by thrombocytopaenia. Malignancy was the underlying cause in 64% of cases; hematolymphoid malignancy was seen in two-thirds and solid malignancies in one-third of the cases. Tuberculosis accounted for 16% of the cases and the etiology was unknown in 12%. Conclusions. The causes of MN are varied and hematological malignancy and solid malignancies are the most common causes. Presence of myelonecrosis is associated with a poor prognosis. Myelonecrosis may obscure the underlying disorder and hence a thorough search in the bone marrow biopsy itself with the help of immunohistochemistry may prove worthwhile in identifying the underlying disease. Hindawi Publishing Corporation 2014 2014-01-23 /pmc/articles/PMC3920973/ /pubmed/24587907 http://dx.doi.org/10.1155/2014/890510 Text en Copyright © 2014 Jinkala Sree Rekha et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Rekha, Jinkala Sree Kar, Rakhee Basu, Debdatta Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period |
title | Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period |
title_full | Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period |
title_fullStr | Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period |
title_full_unstemmed | Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period |
title_short | Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period |
title_sort | myelonecrosis: a clinicopathological study from a tertiary care center in south india over a twelve-year period |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920973/ https://www.ncbi.nlm.nih.gov/pubmed/24587907 http://dx.doi.org/10.1155/2014/890510 |
work_keys_str_mv | AT rekhajinkalasree myelonecrosisaclinicopathologicalstudyfromatertiarycarecenterinsouthindiaoveratwelveyearperiod AT karrakhee myelonecrosisaclinicopathologicalstudyfromatertiarycarecenterinsouthindiaoveratwelveyearperiod AT basudebdatta myelonecrosisaclinicopathologicalstudyfromatertiarycarecenterinsouthindiaoveratwelveyearperiod |