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Vascular Endothelium Derived Endothelin-1 Is Required for Normal Heart Function after Chronic Pressure Overload in Mice

BACKGROUND: Endothelin-1 participates in the pathophysiology of heart failure. The reasons for the lack of beneficial effect of endothelin antagonists in heart failure patients remain however speculative. The anti-apoptotic properties of ET-1 on cardiomyocytes could be a reasonable explanation. We t...

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Detalles Bibliográficos
Autores principales:	Heiden, Susi, Vignon-Zellweger, Nicolas, Masuda, Shigeru, Yagi, Keiko, Nakayama, Kazuhiko, Yanagisawa, Masashi, Emoto, Noriaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921186/ https://www.ncbi.nlm.nih.gov/pubmed/24523936 http://dx.doi.org/10.1371/journal.pone.0088730

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