Impact of STAT1 and CD8(+) T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors

We have recently demonstrated that CD8(+) T cells provide a critical contribution to the antineoplastic activity of 2 chemotherapeutic agents, i.e., doxorubicin and lapatinib, in a model of spontaneous mammary carcinogenesis. The activation of CD8(+) T cells and their recruitment to neoplastic lesio...

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Detalles Bibliográficos
Autores principales: Tymoszuk, Piotr, Doppler, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921202/
https://www.ncbi.nlm.nih.gov/pubmed/24527364
http://dx.doi.org/10.4161/onci.26689
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author Tymoszuk, Piotr
Doppler, Wolfgang
author_facet Tymoszuk, Piotr
Doppler, Wolfgang
author_sort Tymoszuk, Piotr
collection PubMed
description We have recently demonstrated that CD8(+) T cells provide a critical contribution to the antineoplastic activity of 2 chemotherapeutic agents, i.e., doxorubicin and lapatinib, in a model of spontaneous mammary carcinogenesis. The activation of CD8(+) T cells and their recruitment to neoplastic lesions turned out to rely on signal transduction and activator of transcription 1 (STAT1). Accordingly, STAT1-deficient tumor-bearing mice exhibited an impaired response to chemotherapy.
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spelling pubmed-39212022014-02-13 Impact of STAT1 and CD8(+) T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors Tymoszuk, Piotr Doppler, Wolfgang Oncoimmunology Author's View We have recently demonstrated that CD8(+) T cells provide a critical contribution to the antineoplastic activity of 2 chemotherapeutic agents, i.e., doxorubicin and lapatinib, in a model of spontaneous mammary carcinogenesis. The activation of CD8(+) T cells and their recruitment to neoplastic lesions turned out to rely on signal transduction and activator of transcription 1 (STAT1). Accordingly, STAT1-deficient tumor-bearing mice exhibited an impaired response to chemotherapy. Landes Bioscience 2013-12-01 2013-10-22 /pmc/articles/PMC3921202/ /pubmed/24527364 http://dx.doi.org/10.4161/onci.26689 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Tymoszuk, Piotr
Doppler, Wolfgang
Impact of STAT1 and CD8(+) T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors
title Impact of STAT1 and CD8(+) T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors
title_full Impact of STAT1 and CD8(+) T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors
title_fullStr Impact of STAT1 and CD8(+) T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors
title_full_unstemmed Impact of STAT1 and CD8(+) T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors
title_short Impact of STAT1 and CD8(+) T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors
title_sort impact of stat1 and cd8(+) t cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921202/
https://www.ncbi.nlm.nih.gov/pubmed/24527364
http://dx.doi.org/10.4161/onci.26689
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