Decreased Store Operated Ca(2+) Entry in Dendritic Cells Isolated from Mice Expressing PKB/SGK-Resistant GSK3

Dendritic cells (DCs), key players of immunity, are regulated by glycogen synthase kinase GSK3. GSK3 activity is suppressed by PKB/Akt and SGK isoforms, which are in turn stimulated by the PI3K pathway. Exposure to bacterial lipopolysaccharides increases cytosolic Ca(2+)-concentration ([Ca(2+)](i)),...

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Detalles Bibliográficos
Autores principales: Schmid, Evi, Yan, Jing, Nurbaeva, Meerim K., Russo, Antonella, Yang, Wenting, Faggio, Caterina, Shumilina, Ekaterina, Lang, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921210/
https://www.ncbi.nlm.nih.gov/pubmed/24523925
http://dx.doi.org/10.1371/journal.pone.0088637

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