Cargando…

Generation of TALEN-Mediated GR(dim) Knock-In Rats by Homologous Recombination

Transcription Activator-Like Effector Nucleases (TALEN) are potential tools for precise genome engineering of laboratory animals. We report the first targeted genomic integration in the rat using TALENs (Transcription Activator-Like Effector Nucleases) by homology-derived recombination (HDR). We ass...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ponce de León, Verónica, Mérillat, Anne-Marie, Tesson, Laurent, Anegón, Ignacio, Hummler, Edith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921256/ https://www.ncbi.nlm.nih.gov/pubmed/24523878 http://dx.doi.org/10.1371/journal.pone.0088146

Ejemplares similares

Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins
por: Ménoret, Séverine, et al.
Publicado: (2015)

TALEN-mediated homologous recombination in Daphnia magna
por: Nakanishi, Takashi, et al.
Publicado: (2015)

Homologous Recombination-Independent Large Gene Cassette Knock-in in CHO Cells Using TALEN and MMEJ-Directed Donor Plasmids
por: Sakuma, Tetsushi, et al.
Publicado: (2015)

TALEN-mediated knock-in via non-homologous end joining in the crustacean Daphnia magna
por: Nakanishi, Takashi, et al.
Publicado: (2016)

Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats
por: Jung, Chris J., et al.
Publicado: (2016)

Salt-Sensitive Hypertension in GR(+/−) Rats Is Accompanied with Dysregulation in Adrenal Soluble Epoxide Hydrolase and Polyunsaturated Fatty Acid Pathways
por: Vanderriele, Paul-Emmanuel, et al.
Publicado: (2021)

Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modify the Drosophila genome
por: Yu, Zhongsheng, et al.
Publicado: (2014)

RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency
por: Song, Jun, et al.
Publicado: (2016)

Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes
por: Crispo, M., et al.
Publicado: (2015)

In Mice, Tuberculosis Progression Is Associated with Intensive Inflammatory Response and the Accumulation of Gr-1(dim) Cells in the Lungs
por: Lyadova, Irina V., et al.
Publicado: (2010)

Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models
por: Chenouard, Vanessa, et al.
Publicado: (2021)

Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs
por: Yao, Jing, et al.
Publicado: (2014)

Targeting Human α-Lactalbumin Gene Insertion into the Goat β-Lactoglobulin Locus by TALEN-Mediated Homologous Recombination
por: Zhu, Hongmei, et al.
Publicado: (2016)

A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models
por: Frank, Stefan, et al.
Publicado: (2013)

Generate TALE/TALEN as Easily and Rapidly as Generating CRISPR
por: Zhang, Shuyan, et al.
Publicado: (2019)

Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk
por: Cui, Chenchen, et al.
Publicado: (2015)

The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos
por: Miyamoto, Kei, et al.
Publicado: (2015)

Generation of TALEN-mediated FH knockout rat model
por: Yu, Dandan, et al.
Publicado: (2016)

Analyzing structure–function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells
por: Rank, Lisa, et al.
Publicado: (2016)

E-TALEN: a web tool to design TALENs for genome engineering
por: Heigwer, Florian, et al.
Publicado: (2013)

TALEN-Based HvMPK3 Knock-Out Attenuates Proteome and Root Hair Phenotypic Responses to flg22 in Barley
por: Takáč, Tomáš, et al.
Publicado: (2021)

Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases
por: Remy, Séverine, et al.
Publicado: (2014)

Immunosuppressive role of fibrinogen-like protein 2 (FGL2) in CD8(+)regulatory T cells-mediated long-term graft survival
por: Bézie, Séverine, et al.
Publicado: (2011)

GR Dimerization and the Impact of GR Dimerization on GR Protein Stability and Half-Life
por: Louw, Ann
Publicado: (2019)

Targeting DNA With Fingers and TALENs
por: Carlson, Daniel F, et al.
Publicado: (2012)

Targeted Modification of Gene Function Exploiting Homology-Directed Repair of TALEN-Mediated Double-Strand Breaks in Barley
por: Budhagatapalli, Nagaveni, et al.
Publicado: (2015)

Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice
por: Zhang, Jingjing, et al.
Publicado: (2016)

How homologous recombination generates a mutable genome
por: Hurles, Matthew
Publicado: (2005)

TALEN-based generation of a cynomolgus monkey disease model for human microcephaly
por: Ke, Qiong, et al.
Publicado: (2016)

CD56(dim)CD16(dim) Natural Killer (NK) Cells: The Forgotten Population
por: Zimmer, Jacques
Publicado: (2020)

TALEN/CRISPR-Mediated eGFP Knock-In Add-On at the OCT4 Locus Does Not Impact Differentiation of Human Embryonic Stem Cells towards Endoderm
por: Krentz, Nicole A. J., et al.
Publicado: (2014)

Transgenesis and genome analysis, Nantes, France, June 6th 2011
por: Ménoret, Séverine, et al.
Publicado: (2011)

Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation
por: Remy, Séverine, et al.
Publicado: (2017)

Comparison of TALEN scaffolds in Xenopus tropicalis
por: Nakajima, Keisuke, et al.
Publicado: (2013)

Plant genome editing with TALEN and CRISPR
por: Malzahn, Aimee, et al.
Publicado: (2017)

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs
por: Cade, Lindsay, et al.
Publicado: (2012)

Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome
por: Dahlem, Timothy J., et al.
Publicado: (2012)

Generation of Ugt1-Deficient Murine Liver Cell Lines Using TALEN Technology
por: Porro, Fabiola, et al.
Publicado: (2014)

Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs
por: Xin, Jige, et al.
Publicado: (2013)

Efficient generation of B2m-null pigs via injection of zygote with TALENs
por: Wang, Yong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4993tns1mu3eraa2u4ip287rrt