Systemic Effects of Wood Smoke in a Short-Term Experimental Exposure Study of Atopic Volunteers

OBJECTIVE: To investigate whether short-term systemic effects of wood smoke occurred in atopic subjects after experimental wood smoke exposures. METHODS: A double-blind climate chamber study was conducted on 20 healthy atopic subjects with exposures to filtered air and wood smoke. Pneumoproteins, co...

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Autores principales: Bønløkke, Jakob Hjort, Riddervold, Ingunn Skogstad, Grønborg, Therese Koops, Skogstrand, Kristin, Hougaard, David M., Barregard, Lars, Sigsgaard, Torben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Ewers/Celia Braithwait 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921260/
https://www.ncbi.nlm.nih.gov/pubmed/24451613
http://dx.doi.org/10.1097/JOM.0000000000000067
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author Bønløkke, Jakob Hjort
Riddervold, Ingunn Skogstad
Grønborg, Therese Koops
Skogstrand, Kristin
Hougaard, David M.
Barregard, Lars
Sigsgaard, Torben
author_facet Bønløkke, Jakob Hjort
Riddervold, Ingunn Skogstad
Grønborg, Therese Koops
Skogstrand, Kristin
Hougaard, David M.
Barregard, Lars
Sigsgaard, Torben
author_sort Bønløkke, Jakob Hjort
collection PubMed
description OBJECTIVE: To investigate whether short-term systemic effects of wood smoke occurred in atopic subjects after experimental wood smoke exposures. METHODS: A double-blind climate chamber study was conducted on 20 healthy atopic subjects with exposures to filtered air and wood smoke. Pneumoproteins, coagulation and adhesion factors, and cytokines were measured. Heart rate was monitored with pulse monitors. Data were analyzed with mixed models. RESULTS: Few differences in the outcomes were observed. Plasma tissue factor remained elevated during filtered air exposure (P = 0.002). P-selectin declined independent of exposure (P = 0.0006). Interleukin-6 increased after filtered air (P = 0.03). CONCLUSIONS: The study confirmed previous observations among nonatopics of limited changes after a 3-hour wood smoke exposure.
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spelling pubmed-39212602014-02-12 Systemic Effects of Wood Smoke in a Short-Term Experimental Exposure Study of Atopic Volunteers Bønløkke, Jakob Hjort Riddervold, Ingunn Skogstad Grønborg, Therese Koops Skogstrand, Kristin Hougaard, David M. Barregard, Lars Sigsgaard, Torben J Occup Environ Med Original Articles OBJECTIVE: To investigate whether short-term systemic effects of wood smoke occurred in atopic subjects after experimental wood smoke exposures. METHODS: A double-blind climate chamber study was conducted on 20 healthy atopic subjects with exposures to filtered air and wood smoke. Pneumoproteins, coagulation and adhesion factors, and cytokines were measured. Heart rate was monitored with pulse monitors. Data were analyzed with mixed models. RESULTS: Few differences in the outcomes were observed. Plasma tissue factor remained elevated during filtered air exposure (P = 0.002). P-selectin declined independent of exposure (P = 0.0006). Interleukin-6 increased after filtered air (P = 0.03). CONCLUSIONS: The study confirmed previous observations among nonatopics of limited changes after a 3-hour wood smoke exposure. John Ewers/Celia Braithwait 2014-02 2014-02-06 /pmc/articles/PMC3921260/ /pubmed/24451613 http://dx.doi.org/10.1097/JOM.0000000000000067 Text en © 2014 by American College of Occupational and Environmental Medicine http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Original Articles
Bønløkke, Jakob Hjort
Riddervold, Ingunn Skogstad
Grønborg, Therese Koops
Skogstrand, Kristin
Hougaard, David M.
Barregard, Lars
Sigsgaard, Torben
Systemic Effects of Wood Smoke in a Short-Term Experimental Exposure Study of Atopic Volunteers
title Systemic Effects of Wood Smoke in a Short-Term Experimental Exposure Study of Atopic Volunteers
title_full Systemic Effects of Wood Smoke in a Short-Term Experimental Exposure Study of Atopic Volunteers
title_fullStr Systemic Effects of Wood Smoke in a Short-Term Experimental Exposure Study of Atopic Volunteers
title_full_unstemmed Systemic Effects of Wood Smoke in a Short-Term Experimental Exposure Study of Atopic Volunteers
title_short Systemic Effects of Wood Smoke in a Short-Term Experimental Exposure Study of Atopic Volunteers
title_sort systemic effects of wood smoke in a short-term experimental exposure study of atopic volunteers
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921260/
https://www.ncbi.nlm.nih.gov/pubmed/24451613
http://dx.doi.org/10.1097/JOM.0000000000000067
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