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Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921445/ https://www.ncbi.nlm.nih.gov/pubmed/24243224 http://dx.doi.org/10.1007/s10856-013-5091-2 |
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author | Azevedo, A. S. Sá, M. J. C. Fook, M. V. L. Neto, P. I. Nóbrega Sousa, O. B. Azevedo, S. S. Teixeira, M. W. Costa, F. S. Araújo, A. L. |
author_facet | Azevedo, A. S. Sá, M. J. C. Fook, M. V. L. Neto, P. I. Nóbrega Sousa, O. B. Azevedo, S. S. Teixeira, M. W. Costa, F. S. Araújo, A. L. |
author_sort | Azevedo, A. S. |
collection | PubMed |
description | The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided into two experimental time points, with six animals euthanized 45 days after surgery and six euthanized 90 days after surgery. We performed two osteotomies in each tibia. The left tibia was used for the chitosan (QUI) and control groups, and the right tibia was used for the β-TCP alone and in combination with chitosan (QUI+TCP) groups. Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups. Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair. Morphometric analysis showed that treatment groups presented statistically higher bone formation compared with the control group. |
format | Online Article Text |
id | pubmed-3921445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-39214452014-02-19 Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits Azevedo, A. S. Sá, M. J. C. Fook, M. V. L. Neto, P. I. Nóbrega Sousa, O. B. Azevedo, S. S. Teixeira, M. W. Costa, F. S. Araújo, A. L. J Mater Sci Mater Med Article The aim of this research was to evaluate the process of bone regeneration in rabbits, using chitosan and beta-tricalcium phosphate (β-TCP) independently and in combination. A total of 12 New Zealand rabbits of both sexes, with average weight of 3.0 ± 0.57 kg were used. Animals were randomly divided into two experimental time points, with six animals euthanized 45 days after surgery and six euthanized 90 days after surgery. We performed two osteotomies in each tibia. The left tibia was used for the chitosan (QUI) and control groups, and the right tibia was used for the β-TCP alone and in combination with chitosan (QUI+TCP) groups. Tomographic evaluation showed no statistically significant difference among groups; however radiopacity was higher in the treated groups. Comparative descriptive histological evaluation found that treatment groups stimulated a more pronounced tissue repair reaction and accelerated bone repair. Morphometric analysis showed that treatment groups presented statistically higher bone formation compared with the control group. Springer US 2013-11-17 2014 /pmc/articles/PMC3921445/ /pubmed/24243224 http://dx.doi.org/10.1007/s10856-013-5091-2 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article Azevedo, A. S. Sá, M. J. C. Fook, M. V. L. Neto, P. I. Nóbrega Sousa, O. B. Azevedo, S. S. Teixeira, M. W. Costa, F. S. Araújo, A. L. Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits |
title | Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits |
title_full | Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits |
title_fullStr | Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits |
title_full_unstemmed | Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits |
title_short | Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits |
title_sort | use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921445/ https://www.ncbi.nlm.nih.gov/pubmed/24243224 http://dx.doi.org/10.1007/s10856-013-5091-2 |
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