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Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications
Human spiral ganglion (SG) neurons show remarkable survival properties and maintain electric excitability for a long time after complete deafness and even separation from the organ of Corti, features essential for cochlear implantation. Here, we analyze and compare the localization and distribution...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921454/ https://www.ncbi.nlm.nih.gov/pubmed/24241398 http://dx.doi.org/10.1007/s00441-013-1735-2 |
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author | Liu, Wei Glueckert, Rudolf Linthicum, Fred H. Rieger, Gunde Blumer, Michael Bitsche, Mario Pechriggl, Elisabeth Rask-Andersen, Helge Schrott-Fischer, Annelies |
author_facet | Liu, Wei Glueckert, Rudolf Linthicum, Fred H. Rieger, Gunde Blumer, Michael Bitsche, Mario Pechriggl, Elisabeth Rask-Andersen, Helge Schrott-Fischer, Annelies |
author_sort | Liu, Wei |
collection | PubMed |
description | Human spiral ganglion (SG) neurons show remarkable survival properties and maintain electric excitability for a long time after complete deafness and even separation from the organ of Corti, features essential for cochlear implantation. Here, we analyze and compare the localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding SG cell bodies in man and guinea pig by using transmission electron microscopy and confocal immunohistochemistry. GJs and Cx43 expression has been recognized in satellite glial cells (SGCs) in non-myelinating sensory ganglia including the human SG. In man, SG neurons can survive as mono-polar or “amputated” cells with unbroken central projections following dendrite degeneration and consolidation of the dendrite pole. Cx43-mediated GJ signaling between SGCs is believed to play a key role in this “healing” process and could explain the unique preservation of human SG neurons and the persistence of cochlear implant function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00441-013-1735-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-3921454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-39214542014-02-19 Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications Liu, Wei Glueckert, Rudolf Linthicum, Fred H. Rieger, Gunde Blumer, Michael Bitsche, Mario Pechriggl, Elisabeth Rask-Andersen, Helge Schrott-Fischer, Annelies Cell Tissue Res Regular Article Human spiral ganglion (SG) neurons show remarkable survival properties and maintain electric excitability for a long time after complete deafness and even separation from the organ of Corti, features essential for cochlear implantation. Here, we analyze and compare the localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding SG cell bodies in man and guinea pig by using transmission electron microscopy and confocal immunohistochemistry. GJs and Cx43 expression has been recognized in satellite glial cells (SGCs) in non-myelinating sensory ganglia including the human SG. In man, SG neurons can survive as mono-polar or “amputated” cells with unbroken central projections following dendrite degeneration and consolidation of the dendrite pole. Cx43-mediated GJ signaling between SGCs is believed to play a key role in this “healing” process and could explain the unique preservation of human SG neurons and the persistence of cochlear implant function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00441-013-1735-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2013-11-17 2014 /pmc/articles/PMC3921454/ /pubmed/24241398 http://dx.doi.org/10.1007/s00441-013-1735-2 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License, which permits any use, distribution and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Regular Article Liu, Wei Glueckert, Rudolf Linthicum, Fred H. Rieger, Gunde Blumer, Michael Bitsche, Mario Pechriggl, Elisabeth Rask-Andersen, Helge Schrott-Fischer, Annelies Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications |
title | Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications |
title_full | Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications |
title_fullStr | Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications |
title_full_unstemmed | Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications |
title_short | Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications |
title_sort | possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (sgcs) for preservation of human spiral ganglion neurons: a comparative study with clinical implications |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921454/ https://www.ncbi.nlm.nih.gov/pubmed/24241398 http://dx.doi.org/10.1007/s00441-013-1735-2 |
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