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Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications

Human spiral ganglion (SG) neurons show remarkable survival properties and maintain electric excitability for a long time after complete deafness and even separation from the organ of Corti, features essential for cochlear implantation. Here, we analyze and compare the localization and distribution...

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Autores principales: Liu, Wei, Glueckert, Rudolf, Linthicum, Fred H., Rieger, Gunde, Blumer, Michael, Bitsche, Mario, Pechriggl, Elisabeth, Rask-Andersen, Helge, Schrott-Fischer, Annelies
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921454/
https://www.ncbi.nlm.nih.gov/pubmed/24241398
http://dx.doi.org/10.1007/s00441-013-1735-2
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author Liu, Wei
Glueckert, Rudolf
Linthicum, Fred H.
Rieger, Gunde
Blumer, Michael
Bitsche, Mario
Pechriggl, Elisabeth
Rask-Andersen, Helge
Schrott-Fischer, Annelies
author_facet Liu, Wei
Glueckert, Rudolf
Linthicum, Fred H.
Rieger, Gunde
Blumer, Michael
Bitsche, Mario
Pechriggl, Elisabeth
Rask-Andersen, Helge
Schrott-Fischer, Annelies
author_sort Liu, Wei
collection PubMed
description Human spiral ganglion (SG) neurons show remarkable survival properties and maintain electric excitability for a long time after complete deafness and even separation from the organ of Corti, features essential for cochlear implantation. Here, we analyze and compare the localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding SG cell bodies in man and guinea pig by using transmission electron microscopy and confocal immunohistochemistry. GJs and Cx43 expression has been recognized in satellite glial cells (SGCs) in non-myelinating sensory ganglia including the human SG. In man, SG neurons can survive as mono-polar or “amputated” cells with unbroken central projections following dendrite degeneration and consolidation of the dendrite pole. Cx43-mediated GJ signaling between SGCs is believed to play a key role in this “healing” process and could explain the unique preservation of human SG neurons and the persistence of cochlear implant function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00441-013-1735-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-39214542014-02-19 Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications Liu, Wei Glueckert, Rudolf Linthicum, Fred H. Rieger, Gunde Blumer, Michael Bitsche, Mario Pechriggl, Elisabeth Rask-Andersen, Helge Schrott-Fischer, Annelies Cell Tissue Res Regular Article Human spiral ganglion (SG) neurons show remarkable survival properties and maintain electric excitability for a long time after complete deafness and even separation from the organ of Corti, features essential for cochlear implantation. Here, we analyze and compare the localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding SG cell bodies in man and guinea pig by using transmission electron microscopy and confocal immunohistochemistry. GJs and Cx43 expression has been recognized in satellite glial cells (SGCs) in non-myelinating sensory ganglia including the human SG. In man, SG neurons can survive as mono-polar or “amputated” cells with unbroken central projections following dendrite degeneration and consolidation of the dendrite pole. Cx43-mediated GJ signaling between SGCs is believed to play a key role in this “healing” process and could explain the unique preservation of human SG neurons and the persistence of cochlear implant function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00441-013-1735-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2013-11-17 2014 /pmc/articles/PMC3921454/ /pubmed/24241398 http://dx.doi.org/10.1007/s00441-013-1735-2 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License, which permits any use, distribution and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Regular Article
Liu, Wei
Glueckert, Rudolf
Linthicum, Fred H.
Rieger, Gunde
Blumer, Michael
Bitsche, Mario
Pechriggl, Elisabeth
Rask-Andersen, Helge
Schrott-Fischer, Annelies
Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications
title Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications
title_full Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications
title_fullStr Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications
title_full_unstemmed Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications
title_short Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons: A comparative study with clinical implications
title_sort possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (sgcs) for preservation of human spiral ganglion neurons: a comparative study with clinical implications
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921454/
https://www.ncbi.nlm.nih.gov/pubmed/24241398
http://dx.doi.org/10.1007/s00441-013-1735-2
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