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All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation
Neuro-prosthetic devices aim to restore impaired function through artificial stimulation of the nervous system. A lingering technological bottleneck in this field is the realization of soft, micron sized electrodes capable of injecting enough charge to evoke localized neuronal activity without causi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921458/ https://www.ncbi.nlm.nih.gov/pubmed/23974529 http://dx.doi.org/10.1007/s10544-013-9804-6 |
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author | David-Pur, Moshe Bareket-Keren, Lilach Beit-Yaakov, Giora Raz-Prag, Dorit Hanein, Yael |
author_facet | David-Pur, Moshe Bareket-Keren, Lilach Beit-Yaakov, Giora Raz-Prag, Dorit Hanein, Yael |
author_sort | David-Pur, Moshe |
collection | PubMed |
description | Neuro-prosthetic devices aim to restore impaired function through artificial stimulation of the nervous system. A lingering technological bottleneck in this field is the realization of soft, micron sized electrodes capable of injecting enough charge to evoke localized neuronal activity without causing neither electrode nor tissue damage. Direct stimulation with micro electrodes will offer the high efficacy needed in applications such as cochlear and retinal implants. Here we present a new flexible neuronal micro electrode device, based entirely on carbon nanotube technology, where both the conducting traces and the stimulating electrodes consist of conducting carbon nanotube films embedded in a polymeric support. The use of carbon nanotubes bestows the electrodes flexibility and excellent electrochemical properties. As opposed to contemporary flexible neuronal electrodes, the technology presented here is both robust and the resulting stimulating electrodes are nearly purely capacitive. Recording and stimulation tests with chick retinas were used to validate the advantageous properties of the electrodes and demonstrate their suitability for high-efficacy neuronal stimulation applications. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10544-013-9804-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-3921458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-39214582014-02-19 All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation David-Pur, Moshe Bareket-Keren, Lilach Beit-Yaakov, Giora Raz-Prag, Dorit Hanein, Yael Biomed Microdevices Article Neuro-prosthetic devices aim to restore impaired function through artificial stimulation of the nervous system. A lingering technological bottleneck in this field is the realization of soft, micron sized electrodes capable of injecting enough charge to evoke localized neuronal activity without causing neither electrode nor tissue damage. Direct stimulation with micro electrodes will offer the high efficacy needed in applications such as cochlear and retinal implants. Here we present a new flexible neuronal micro electrode device, based entirely on carbon nanotube technology, where both the conducting traces and the stimulating electrodes consist of conducting carbon nanotube films embedded in a polymeric support. The use of carbon nanotubes bestows the electrodes flexibility and excellent electrochemical properties. As opposed to contemporary flexible neuronal electrodes, the technology presented here is both robust and the resulting stimulating electrodes are nearly purely capacitive. Recording and stimulation tests with chick retinas were used to validate the advantageous properties of the electrodes and demonstrate their suitability for high-efficacy neuronal stimulation applications. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10544-013-9804-6) contains supplementary material, which is available to authorized users. Springer US 2013-08-24 2014 /pmc/articles/PMC3921458/ /pubmed/23974529 http://dx.doi.org/10.1007/s10544-013-9804-6 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article David-Pur, Moshe Bareket-Keren, Lilach Beit-Yaakov, Giora Raz-Prag, Dorit Hanein, Yael All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation |
title | All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation |
title_full | All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation |
title_fullStr | All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation |
title_full_unstemmed | All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation |
title_short | All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation |
title_sort | all-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921458/ https://www.ncbi.nlm.nih.gov/pubmed/23974529 http://dx.doi.org/10.1007/s10544-013-9804-6 |
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