Hypocretin (orexin) regulation of sleep-to-wake transitions

The hypocretin (Hcrt), also known as orexin, peptides are essential for arousal stability. Here we discuss background information about the interaction of Hcrt with other neuromodulators, including norepinephrine and acetylcholine probed with optogenetics. We conclude that Hcrt neurons integrate met...

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Detalles Bibliográficos
Autores principales: de Lecea, Luis, Huerta, Ramón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921570/
https://www.ncbi.nlm.nih.gov/pubmed/24575043
http://dx.doi.org/10.3389/fphar.2014.00016
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author de Lecea, Luis
Huerta, Ramón
author_facet de Lecea, Luis
Huerta, Ramón
author_sort de Lecea, Luis
collection PubMed
description The hypocretin (Hcrt), also known as orexin, peptides are essential for arousal stability. Here we discuss background information about the interaction of Hcrt with other neuromodulators, including norepinephrine and acetylcholine probed with optogenetics. We conclude that Hcrt neurons integrate metabolic, circadian and limbic inputs and convey this information to a network of neuromodulators, each of which has a different role on the dynamic of sleep-to-wake transitions. This model may prove useful to predict the effects of orexin receptor antagonists in sleep disorders and other conditions.
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spelling pubmed-39215702014-02-26 Hypocretin (orexin) regulation of sleep-to-wake transitions de Lecea, Luis Huerta, Ramón Front Pharmacol Pharmacology The hypocretin (Hcrt), also known as orexin, peptides are essential for arousal stability. Here we discuss background information about the interaction of Hcrt with other neuromodulators, including norepinephrine and acetylcholine probed with optogenetics. We conclude that Hcrt neurons integrate metabolic, circadian and limbic inputs and convey this information to a network of neuromodulators, each of which has a different role on the dynamic of sleep-to-wake transitions. This model may prove useful to predict the effects of orexin receptor antagonists in sleep disorders and other conditions. Frontiers Media S.A. 2014-02-12 /pmc/articles/PMC3921570/ /pubmed/24575043 http://dx.doi.org/10.3389/fphar.2014.00016 Text en Copyright © 2014 de Lecea and Huerta. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
de Lecea, Luis
Huerta, Ramón
Hypocretin (orexin) regulation of sleep-to-wake transitions
title Hypocretin (orexin) regulation of sleep-to-wake transitions
title_full Hypocretin (orexin) regulation of sleep-to-wake transitions
title_fullStr Hypocretin (orexin) regulation of sleep-to-wake transitions
title_full_unstemmed Hypocretin (orexin) regulation of sleep-to-wake transitions
title_short Hypocretin (orexin) regulation of sleep-to-wake transitions
title_sort hypocretin (orexin) regulation of sleep-to-wake transitions
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921570/
https://www.ncbi.nlm.nih.gov/pubmed/24575043
http://dx.doi.org/10.3389/fphar.2014.00016
work_keys_str_mv AT delecealuis hypocretinorexinregulationofsleeptowaketransitions
AT huertaramon hypocretinorexinregulationofsleeptowaketransitions

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