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Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria
Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Global Advances in Health and Medicine
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921613/ https://www.ncbi.nlm.nih.gov/pubmed/24753992 http://dx.doi.org/10.7453/gahmj.2013.011 |
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author | Vigil, Michael Berkson, Burton M. Garcia, Ana Patricia |
author_facet | Vigil, Michael Berkson, Burton M. Garcia, Ana Patricia |
author_sort | Vigil, Michael |
collection | PubMed |
description | Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent. |
format | Online Article Text |
id | pubmed-3921613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Global Advances in Health and Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-39216132015-01-01 Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria Vigil, Michael Berkson, Burton M. Garcia, Ana Patricia Glob Adv Health Med Original Research Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent. Global Advances in Health and Medicine 2014-01 2014-01-01 /pmc/articles/PMC3921613/ /pubmed/24753992 http://dx.doi.org/10.7453/gahmj.2013.011 Text en © 2014 GAHM LLC. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial- No Derivative 3.0 License, which permits rights to copy, distribute and transmit the work for noncommercial purposes only, provided the original work is properly cited. |
spellingShingle | Original Research Vigil, Michael Berkson, Burton M. Garcia, Ana Patricia Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria |
title | Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria |
title_full | Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria |
title_fullStr | Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria |
title_full_unstemmed | Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria |
title_short | Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria |
title_sort | adverse effects of high doses of intravenous alpha lipoic acid on liver mitochondria |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921613/ https://www.ncbi.nlm.nih.gov/pubmed/24753992 http://dx.doi.org/10.7453/gahmj.2013.011 |
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