Cargando…

Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria

Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissu...

Descripción completa

Detalles Bibliográficos
Autores principales: Vigil, Michael, Berkson, Burton M., Garcia, Ana Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Global Advances in Health and Medicine 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921613/
https://www.ncbi.nlm.nih.gov/pubmed/24753992
http://dx.doi.org/10.7453/gahmj.2013.011
_version_ 1782303319026302976
author Vigil, Michael
Berkson, Burton M.
Garcia, Ana Patricia
author_facet Vigil, Michael
Berkson, Burton M.
Garcia, Ana Patricia
author_sort Vigil, Michael
collection PubMed
description Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent.
format Online
Article
Text
id pubmed-3921613
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Global Advances in Health and Medicine
record_format MEDLINE/PubMed
spelling pubmed-39216132015-01-01 Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria Vigil, Michael Berkson, Burton M. Garcia, Ana Patricia Glob Adv Health Med Original Research Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent. Global Advances in Health and Medicine 2014-01 2014-01-01 /pmc/articles/PMC3921613/ /pubmed/24753992 http://dx.doi.org/10.7453/gahmj.2013.011 Text en © 2014 GAHM LLC. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial- No Derivative 3.0 License, which permits rights to copy, distribute and transmit the work for noncommercial purposes only, provided the original work is properly cited.
spellingShingle Original Research
Vigil, Michael
Berkson, Burton M.
Garcia, Ana Patricia
Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria
title Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria
title_full Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria
title_fullStr Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria
title_full_unstemmed Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria
title_short Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria
title_sort adverse effects of high doses of intravenous alpha lipoic acid on liver mitochondria
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921613/
https://www.ncbi.nlm.nih.gov/pubmed/24753992
http://dx.doi.org/10.7453/gahmj.2013.011
work_keys_str_mv AT vigilmichael adverseeffectsofhighdosesofintravenousalphalipoicacidonlivermitochondria
AT berksonburtonm adverseeffectsofhighdosesofintravenousalphalipoicacidonlivermitochondria
AT garciaanapatricia adverseeffectsofhighdosesofintravenousalphalipoicacidonlivermitochondria