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Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P)

INTRODUCTION: Postoperative blood loss after prostate surgery is thought to be associated with an increase in urinary fibrinolytic activity. Tranexamic acid (TXA) is both a potent inhibitor of plasminogen and urokinase activators and a low molecular weight substance that is excreted unchanged in the...

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Autores principales: Kumsar, Şükrü, Dirim, Ayhan, Toksöz, Serdar, Sağlam, Hasan S., Adsan, Öztuğ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Urological Association 2011
Materias:
BPH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921720/
https://www.ncbi.nlm.nih.gov/pubmed/24578884
http://dx.doi.org/10.5173/ceju.2011.03.art13
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author Kumsar, Şükrü
Dirim, Ayhan
Toksöz, Serdar
Sağlam, Hasan S.
Adsan, Öztuğ
author_facet Kumsar, Şükrü
Dirim, Ayhan
Toksöz, Serdar
Sağlam, Hasan S.
Adsan, Öztuğ
author_sort Kumsar, Şükrü
collection PubMed
description INTRODUCTION: Postoperative blood loss after prostate surgery is thought to be associated with an increase in urinary fibrinolytic activity. Tranexamic acid (TXA) is both a potent inhibitor of plasminogen and urokinase activators and a low molecular weight substance that is excreted unchanged in the urinary tract and can be administered both orally and intravenously. We investigated the effect of TXA on the amount of blood loss during transurethral resection of the prostate (TURP). MATERIALS AND METHODS: Forty patients with registry numbers ending in even numbers were allocated to the treatment group; those ending in odd numbers were used as controls and received no treatment. The treatment group received 10 mg/kg TXA by intravenous infusion during the first half hour of the operation, while the control group of patients received no medication. Serum hemoglobin was measured before and after surgery. The volume and hemoglobin concentration of the irrigation fluid, resected prostate weight, and duration of resection were recorded. RESULTS: The mean loss of hemoglobin per gram of resected prostate tissue was 1.25 g in the TXA group and 2.84 g in the control group. Total hemoglobin loss in the irrigating fluid and hemoglobin loss per 1 gram of prostate tissue was lower in the group of patients given TXA than in the control group (p = 0.018 and p <0.001). CONCLUSION: Reduced bleeding during TURP as a result of TXA treatment may lead to better surgical conditions and, as a consequence, shorter operative times and lower irrigating fluid volumes.
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spelling pubmed-39217202014-02-27 Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P) Kumsar, Şükrü Dirim, Ayhan Toksöz, Serdar Sağlam, Hasan S. Adsan, Öztuğ Cent European J Urol BPH INTRODUCTION: Postoperative blood loss after prostate surgery is thought to be associated with an increase in urinary fibrinolytic activity. Tranexamic acid (TXA) is both a potent inhibitor of plasminogen and urokinase activators and a low molecular weight substance that is excreted unchanged in the urinary tract and can be administered both orally and intravenously. We investigated the effect of TXA on the amount of blood loss during transurethral resection of the prostate (TURP). MATERIALS AND METHODS: Forty patients with registry numbers ending in even numbers were allocated to the treatment group; those ending in odd numbers were used as controls and received no treatment. The treatment group received 10 mg/kg TXA by intravenous infusion during the first half hour of the operation, while the control group of patients received no medication. Serum hemoglobin was measured before and after surgery. The volume and hemoglobin concentration of the irrigation fluid, resected prostate weight, and duration of resection were recorded. RESULTS: The mean loss of hemoglobin per gram of resected prostate tissue was 1.25 g in the TXA group and 2.84 g in the control group. Total hemoglobin loss in the irrigating fluid and hemoglobin loss per 1 gram of prostate tissue was lower in the group of patients given TXA than in the control group (p = 0.018 and p <0.001). CONCLUSION: Reduced bleeding during TURP as a result of TXA treatment may lead to better surgical conditions and, as a consequence, shorter operative times and lower irrigating fluid volumes. Polish Urological Association 2011-09-06 2011 /pmc/articles/PMC3921720/ /pubmed/24578884 http://dx.doi.org/10.5173/ceju.2011.03.art13 Text en Copyright by Polish Urological Association http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle BPH
Kumsar, Şükrü
Dirim, Ayhan
Toksöz, Serdar
Sağlam, Hasan S.
Adsan, Öztuğ
Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P)
title Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P)
title_full Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P)
title_fullStr Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P)
title_full_unstemmed Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P)
title_short Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P)
title_sort tranexamic acid decreases blood loss during transurethral resection of the prostate (tur -p)
topic BPH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921720/
https://www.ncbi.nlm.nih.gov/pubmed/24578884
http://dx.doi.org/10.5173/ceju.2011.03.art13
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