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Factors predicting Gleason score 6 upgrading after radical prostatectomy
OBJECTIVES: Prostate cancer Gleason score 6 is the most common score detected on prostatic biopsy. We analyzed the clinical parameters that predict the likelihood of Gleason score upgrading after radical prostatectomy. METHODS: The study population consisted of 241 patients who underwent radical ret...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Urological Association
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921736/ https://www.ncbi.nlm.nih.gov/pubmed/24578894 http://dx.doi.org/10.5173/ceju.2011.04.art3 |
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author | Milonas, Daimantas Grybas, Aivaras Auskalnis, Stasys Gudinaviciene, Inga Baltrimavicius, Ruslanas Kincius, Marius Jievaltas, Mindaugas |
author_facet | Milonas, Daimantas Grybas, Aivaras Auskalnis, Stasys Gudinaviciene, Inga Baltrimavicius, Ruslanas Kincius, Marius Jievaltas, Mindaugas |
author_sort | Milonas, Daimantas |
collection | PubMed |
description | OBJECTIVES: Prostate cancer Gleason score 6 is the most common score detected on prostatic biopsy. We analyzed the clinical parameters that predict the likelihood of Gleason score upgrading after radical prostatectomy. METHODS: The study population consisted of 241 patients who underwent radical retropubic prostatectomy between Feb 2002 and Dec 2007 for Gleason score 6 adenocarcinoma. The influence of preoperative parameters on the probability of a Gleason score upgrading after surgery was evaluated using multivariate logistic regression and ROC curves. RESULTS: Gleason score upgrade was found in 92 of 241 patients (38.2%). Multivariate logistic regression analysis showed that only percentage of cancer in dominant lobe and prostate weight were significant predictors for Gleason score upgrading (p = 0.043 and p = 0.006, respectively). ROC curves showed that prostate weight and PSA density were only two independent significant parameters for prediction of upgrade (AUC – 0.634, p <0.0001 and 0.604, p = 0.006, respectively). Gleason score upgrading was observed to be accompanied by significantly higher rates of extra prostatic extension (p <0.001) and seminal vesicle invasion (p = 0.002). CONCLUSIONS: Almost forty percent of tumors graded Gleason 6 at biopsy are Gleason 7 at surgery. Upgraded tumors significantly associated with adverse pathological features. The probability of Gleason score upgrade can be predicted using prostate weight and PSA density as independent parameters. |
format | Online Article Text |
id | pubmed-3921736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Polish Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-39217362014-02-27 Factors predicting Gleason score 6 upgrading after radical prostatectomy Milonas, Daimantas Grybas, Aivaras Auskalnis, Stasys Gudinaviciene, Inga Baltrimavicius, Ruslanas Kincius, Marius Jievaltas, Mindaugas Cent European J Urol Urological Oncology OBJECTIVES: Prostate cancer Gleason score 6 is the most common score detected on prostatic biopsy. We analyzed the clinical parameters that predict the likelihood of Gleason score upgrading after radical prostatectomy. METHODS: The study population consisted of 241 patients who underwent radical retropubic prostatectomy between Feb 2002 and Dec 2007 for Gleason score 6 adenocarcinoma. The influence of preoperative parameters on the probability of a Gleason score upgrading after surgery was evaluated using multivariate logistic regression and ROC curves. RESULTS: Gleason score upgrade was found in 92 of 241 patients (38.2%). Multivariate logistic regression analysis showed that only percentage of cancer in dominant lobe and prostate weight were significant predictors for Gleason score upgrading (p = 0.043 and p = 0.006, respectively). ROC curves showed that prostate weight and PSA density were only two independent significant parameters for prediction of upgrade (AUC – 0.634, p <0.0001 and 0.604, p = 0.006, respectively). Gleason score upgrading was observed to be accompanied by significantly higher rates of extra prostatic extension (p <0.001) and seminal vesicle invasion (p = 0.002). CONCLUSIONS: Almost forty percent of tumors graded Gleason 6 at biopsy are Gleason 7 at surgery. Upgraded tumors significantly associated with adverse pathological features. The probability of Gleason score upgrade can be predicted using prostate weight and PSA density as independent parameters. Polish Urological Association 2011-12-09 2011 /pmc/articles/PMC3921736/ /pubmed/24578894 http://dx.doi.org/10.5173/ceju.2011.04.art3 Text en Copyright by Polish Urological Association http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Urological Oncology Milonas, Daimantas Grybas, Aivaras Auskalnis, Stasys Gudinaviciene, Inga Baltrimavicius, Ruslanas Kincius, Marius Jievaltas, Mindaugas Factors predicting Gleason score 6 upgrading after radical prostatectomy |
title | Factors predicting Gleason score 6 upgrading after radical prostatectomy |
title_full | Factors predicting Gleason score 6 upgrading after radical prostatectomy |
title_fullStr | Factors predicting Gleason score 6 upgrading after radical prostatectomy |
title_full_unstemmed | Factors predicting Gleason score 6 upgrading after radical prostatectomy |
title_short | Factors predicting Gleason score 6 upgrading after radical prostatectomy |
title_sort | factors predicting gleason score 6 upgrading after radical prostatectomy |
topic | Urological Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921736/ https://www.ncbi.nlm.nih.gov/pubmed/24578894 http://dx.doi.org/10.5173/ceju.2011.04.art3 |
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