Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors

Few data are available on patient management in jaundice caused by liver metastases of solid tumors (nonbreast and noncolon origin). We report the first patient series consecutively treated with cisplatin weekly in patients with severe jaundice and liver failure due to underlying metastatic neoplasm...

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Autores principales: Gabrovska, M, Geurs, F, Ponette, S, Ponette, J, Bulte, K, Derveaux, L, Kempeneers, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921826/
https://www.ncbi.nlm.nih.gov/pubmed/24623997
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author Gabrovska, M
Geurs, F
Ponette, S
Ponette, J
Bulte, K
Derveaux, L
Kempeneers, I
author_facet Gabrovska, M
Geurs, F
Ponette, S
Ponette, J
Bulte, K
Derveaux, L
Kempeneers, I
author_sort Gabrovska, M
collection PubMed
description Few data are available on patient management in jaundice caused by liver metastases of solid tumors (nonbreast and noncolon origin). We report the first patient series consecutively treated with cisplatin weekly in patients with severe jaundice and liver failure due to underlying metastatic neoplasms. In 4 out of 8 cases, liver function tests were reversed and jaundice disappeared, permitting subsequent standard chemotherapy. The other 4 patients died 3 to 5 weeks after admission, illustrating the extent and severity of the underlying neoplasm.
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spelling pubmed-39218262014-03-12 Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors Gabrovska, M Geurs, F Ponette, S Ponette, J Bulte, K Derveaux, L Kempeneers, I Hepat Med Original Research Few data are available on patient management in jaundice caused by liver metastases of solid tumors (nonbreast and noncolon origin). We report the first patient series consecutively treated with cisplatin weekly in patients with severe jaundice and liver failure due to underlying metastatic neoplasms. In 4 out of 8 cases, liver function tests were reversed and jaundice disappeared, permitting subsequent standard chemotherapy. The other 4 patients died 3 to 5 weeks after admission, illustrating the extent and severity of the underlying neoplasm. Dove Medical Press 2009-10-30 /pmc/articles/PMC3921826/ /pubmed/24623997 Text en © 2009 Gabrovska et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Gabrovska, M
Geurs, F
Ponette, S
Ponette, J
Bulte, K
Derveaux, L
Kempeneers, I
Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors
title Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors
title_full Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors
title_fullStr Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors
title_full_unstemmed Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors
title_short Weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors
title_sort weekly cisplatin may reverse liver dysfunction and jaundice caused by diffuse liver metastases of solid tumors
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921826/
https://www.ncbi.nlm.nih.gov/pubmed/24623997
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