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Airway remodelling in asthma: role for mechanical forces
Asthma is a chronic airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction. Airway structural changes or airway remodelling consist of epithelial injury, goblet cell hyperplasia, subepithelial layer thickening, airway smoo...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921863/ https://www.ncbi.nlm.nih.gov/pubmed/24527406 http://dx.doi.org/10.5415/apallergy.2014.4.1.19 |
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author | Manuyakorn, Wiparat |
author_facet | Manuyakorn, Wiparat |
author_sort | Manuyakorn, Wiparat |
collection | PubMed |
description | Asthma is a chronic airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction. Airway structural changes or airway remodelling consist of epithelial injury, goblet cell hyperplasia, subepithelial layer thickening, airway smooth muscle hyperplasia and angiogenesis. These changes were previously considered as a consequence of chronic airway inflammation. Even though inhaled corticosteroids can suppress airway inflammation, the natural history of asthma is still unaltered after inhaled corticosteroid treatment. As such there is increasing evidence for the role of mechanical forces within the asthmatic airway contributing to airway structural changes. |
format | Online Article Text |
id | pubmed-3921863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-39218632014-02-13 Airway remodelling in asthma: role for mechanical forces Manuyakorn, Wiparat Asia Pac Allergy Current Review Asthma is a chronic airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction. Airway structural changes or airway remodelling consist of epithelial injury, goblet cell hyperplasia, subepithelial layer thickening, airway smooth muscle hyperplasia and angiogenesis. These changes were previously considered as a consequence of chronic airway inflammation. Even though inhaled corticosteroids can suppress airway inflammation, the natural history of asthma is still unaltered after inhaled corticosteroid treatment. As such there is increasing evidence for the role of mechanical forces within the asthmatic airway contributing to airway structural changes. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2014-01 2014-01-31 /pmc/articles/PMC3921863/ /pubmed/24527406 http://dx.doi.org/10.5415/apallergy.2014.4.1.19 Text en Copyright © 2014. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Current Review Manuyakorn, Wiparat Airway remodelling in asthma: role for mechanical forces |
title | Airway remodelling in asthma: role for mechanical forces |
title_full | Airway remodelling in asthma: role for mechanical forces |
title_fullStr | Airway remodelling in asthma: role for mechanical forces |
title_full_unstemmed | Airway remodelling in asthma: role for mechanical forces |
title_short | Airway remodelling in asthma: role for mechanical forces |
title_sort | airway remodelling in asthma: role for mechanical forces |
topic | Current Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921863/ https://www.ncbi.nlm.nih.gov/pubmed/24527406 http://dx.doi.org/10.5415/apallergy.2014.4.1.19 |
work_keys_str_mv | AT manuyakornwiparat airwayremodellinginasthmaroleformechanicalforces |