Cargando…

Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge

BACKGROUND: The inability of current vaccines to provide effective protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection is not fully understood. One of the reasons might be the presence of anti-idiotypic antibodies (Ab2s) to the envelope glycoprotein GP5 induced b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Ying, Cai, Xuehui, Wang, Gang, Kong, Ning, Liu, Yonggang, Xiao, Yihong, Zhang, Chong, Mu, Yang, Xiao, Shuqi, Zhao, Qin, Wang, Chengbao, Zhang, Gaiping, Hiscox, Julian A, Zhou, En-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921987/ https://www.ncbi.nlm.nih.gov/pubmed/24507659 http://dx.doi.org/10.1186/1746-6148-10-39

Ejemplares similares

Rescue and evaluation of a recombinant PRRSV expressing porcine Interleukin-4
por: Li, Zhijun, et al.
Publicado: (2015)

Efficacy of a live attenuated highly pathogenic PRRSV vaccine against a NADC30-like strain challenge: implications for ADE of PRRSV
por: Chen, Xin-xin, et al.
Publicado: (2021)

Inhibition of highly pathogenic PRRSV replication in MARC-145 cells by artificial microRNAs
por: Xiao, Shuqi, et al.
Publicado: (2011)

MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection
por: Gao, Jiming, et al.
Publicado: (2016)

Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells
por: Shi, Xibao, et al.
Publicado: (2016)

Antiviral Strategies of Chinese Herbal Medicine Against PRRSV Infection
por: Bello-Onaghise, God’spower, et al.
Publicado: (2020)

A Novel Motif in the 3′-UTR of PRRSV-2 Is Critical for Viral Multiplication and Contributes to Enhanced Replication Ability of Highly Pathogenic or L1 PRRSV
por: Xiong, Junyao, et al.
Publicado: (2022)

Proteome changes of lungs artificially infected with H-PRRSV and N-PRRSV by two-dimensional fluorescence difference gel electrophoresis
por: Xiao, Shuqi, et al.
Publicado: (2010)

Intranasal inoculation of sows with highly pathogenic porcine reproductive and respiratory syndrome virus at mid-gestation causes transplacental infection of fetuses
por: Wang, Tongtong, et al.
Publicado: (2015)

Small interfering RNA targeting nonstructural protein1 α (nsp1α) of porcine reproductive and respiratory syndrome virus (PRRSV) can reduce the replication of PRRSV in MARC-145 cells
por: Shi, Xibao, et al.
Publicado: (2015)

Idiotype-recognizing T helper cells that are not idiotype specific
Publicado: (1983)

Idiotypic regulation of the immune system. Common idiotypic specificities between idiotypes and antibodies raised against anti- idiotypic antibodies in rabbits
Publicado: (1979)

Codon Pair Deoptimization (CPD)-Attenuated PRRSV-1 Vaccination Exhibit Immunity to Virulent PRRSV Challenge in Pigs
por: Lee, Min-A, et al.
Publicado: (2023)

TAT Nanobody Exerts Antiviral Effect against PRRSV In Vitro by Targeting Viral Nucleocapsid Protein
por: Ren, Jiahui, et al.
Publicado: (2023)

Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells
Publicado: (1982)

Toward a fractalomic idiotype/anti-idiotypic paradigm
por: Chiappelli, Francesco, et al.
Publicado: (2022)

Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induced Apoptosis and Autophagy in Thymi of Infected Piglets
por: Wang, Gang, et al.
Publicado: (2015)

Simultaneous Detection and Differentiation of Highly Virulent and Classical Chinese-Type Isolation of PRRSV by Real-Time RT-PCR
por: Xiao, Shuqi, et al.
Publicado: (2014)

Aberrant host immune response induced by highly virulent PRRSV identified by digital gene expression tag profiling
por: Xiao, Shuqi, et al.
Publicado: (2010)

Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway
por: Song, Linlin, et al.
Publicado: (2018)

Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein
por: Lu, Wenhui, et al.
Publicado: (2014)

Suppression of idiotype and generation of suppressor T cells with idiotype-conjugated thymocytes
Publicado: (1979)

Deregulation of idiotype expression. Induction of tolerance in an anti- idiotypic response
Publicado: (1982)

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2
por: Chen, Jing, et al.
Publicado: (2015)

A novel porcine reproductive and respiratory syndrome virus vector system that stably expresses enhanced green fluorescent protein as a separate transcription unit
por: Wang, Chengbao, et al.
Publicado: (2013)

Effects of Astragalus Polysaccharide on Immune Responses of Porcine PBMC Stimulated with PRRSV or CSFV
por: Zhuge, Zeng-Yu, et al.
Publicado: (2012)

The molecular characteristic analysis of PRRSV GSWW/2015 strain and its pathogenicity to pigs
por: Bai, Weijie, et al.
Publicado: (2018)

Change of Gut Microbiota in PRRSV-Resistant Pigs and PRRSV-Susceptible Pigs from Tongcheng Pigs and Large White Pigs Crossed Population upon PRRSV Infection
por: Wang, Tengfei, et al.
Publicado: (2022)

Understanding PRRSV Infection in Porcine Lung Based on Genome-Wide Transcriptome Response Identified by Deep Sequencing
por: Xiao, Shuqi, et al.
Publicado: (2010)

Mechanisms of idiotype suppression. I. In vitro generation of idiotype- specific suppressor T cells by anti-idiotype antibodies and specific antigen
Publicado: (1979)

Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti- idiotypic receptors
Publicado: (1980)

Porcine FcγRIIb Mediates Enhancement of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
por: Qiao, Songlin, et al.
Publicado: (2011)

Characterization of Two Immunodominant Antigenic Peptides in NSP2 of PRRSV-2 and Generation of a Marker PRRSV Strain Based on the Peptides
por: Li, Dong-Yan, et al.
Publicado: (2022)

Modification of T cell antinuclease idiotype expression by in vivo administration of anti-idiotype
Publicado: (1982)

Porcine alveolar macrophage polarization is involved in inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication
por: WANG, Longtao, et al.
Publicado: (2017)

A model for the dynamic nuclear/nucleolar/cytoplasmic trafficking of the porcine reproductive and respiratory syndrome virus (PRRSV) nucleocapsid protein based on live cell imaging
por: You, Jae-Hwan, et al.
Publicado: (2008)

Synergistic Pathogenicity by Coinfection and Sequential Infection with NADC30-like PRRSV and PCV2 in Post-Weaned Pigs
por: Zhang, Jinyong, et al.
Publicado: (2022)

The natural compound Sanggenon C inhibits PRRSV infection by regulating the TRAF2/NF-κB signalling pathway
por: Liu, Xiao, et al.
Publicado: (2023)

Mechanism(s) of prolonged attenuation of allergic responses after modulation of idiotypic regulatory network
por: Gorczynski, R. M., et al.
Publicado: (2019)

MicroRNA-like viral small RNA from porcine reproductive and respiratory syndrome virus negatively regulates viral replication by targeting the viral nonstructural protein 2
por: Li, Na, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nt60evv0e8adlpg7n3t2hv42ds