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The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma
BACKGROUND: Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression leve...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922338/ https://www.ncbi.nlm.nih.gov/pubmed/24499297 http://dx.doi.org/10.1186/1476-4598-13-25 |
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author | Zhang, Yao Bao, Li Lu, Jin Liu, Kai-Yan Li, Jin-Lan Qin, Ya-Zhen Chen, Huan Li, Ling-Di Kong, Yuan Shi, Hong-Xia Lai, Yue-Yun Liu, Yan-Rong Jiang, Bin Chen, Shan-Shan Huang, Xiao-Jun Ruan, Guo-Rui |
author_facet | Zhang, Yao Bao, Li Lu, Jin Liu, Kai-Yan Li, Jin-Lan Qin, Ya-Zhen Chen, Huan Li, Ling-Di Kong, Yuan Shi, Hong-Xia Lai, Yue-Yun Liu, Yan-Rong Jiang, Bin Chen, Shan-Shan Huang, Xiao-Jun Ruan, Guo-Rui |
author_sort | Zhang, Yao |
collection | PubMed |
description | BACKGROUND: Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression levels of four CT antigen genes in Chinese patients with MM and explored their clinical implications. METHODS: Real-time quantitative polymerase chain reaction (qPCR) was used to quantify the expression of MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 mRNA in 256 bone marrow samples from 144 MM patients. RESULTS: In the newly diagnosed patients, the positive expression rates were 88.5% for MAGE-C1/CT7, 82.1% for MAGE-C2/CT10, 76.9% for MAGE-A3 and 25.6% for SSX-2. The expression levels and the number of co-expressed CT antigens correlated significantly with several clinical indicators, including the percentage of plasma cells infiltrating the bone marrow, abnormal chromosome karyotypes and the clinical course. CONCLUSION: MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 expression levels provide potentially effective clinical indicators for the auxiliary diagnosis and monitoring of treatment efficacy in MM. |
format | Online Article Text |
id | pubmed-3922338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39223382014-02-13 The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma Zhang, Yao Bao, Li Lu, Jin Liu, Kai-Yan Li, Jin-Lan Qin, Ya-Zhen Chen, Huan Li, Ling-Di Kong, Yuan Shi, Hong-Xia Lai, Yue-Yun Liu, Yan-Rong Jiang, Bin Chen, Shan-Shan Huang, Xiao-Jun Ruan, Guo-Rui Mol Cancer Research BACKGROUND: Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression levels of four CT antigen genes in Chinese patients with MM and explored their clinical implications. METHODS: Real-time quantitative polymerase chain reaction (qPCR) was used to quantify the expression of MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 mRNA in 256 bone marrow samples from 144 MM patients. RESULTS: In the newly diagnosed patients, the positive expression rates were 88.5% for MAGE-C1/CT7, 82.1% for MAGE-C2/CT10, 76.9% for MAGE-A3 and 25.6% for SSX-2. The expression levels and the number of co-expressed CT antigens correlated significantly with several clinical indicators, including the percentage of plasma cells infiltrating the bone marrow, abnormal chromosome karyotypes and the clinical course. CONCLUSION: MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 expression levels provide potentially effective clinical indicators for the auxiliary diagnosis and monitoring of treatment efficacy in MM. BioMed Central 2014-02-05 /pmc/articles/PMC3922338/ /pubmed/24499297 http://dx.doi.org/10.1186/1476-4598-13-25 Text en Copyright © 2014 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Zhang, Yao Bao, Li Lu, Jin Liu, Kai-Yan Li, Jin-Lan Qin, Ya-Zhen Chen, Huan Li, Ling-Di Kong, Yuan Shi, Hong-Xia Lai, Yue-Yun Liu, Yan-Rong Jiang, Bin Chen, Shan-Shan Huang, Xiao-Jun Ruan, Guo-Rui The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma |
title | The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma |
title_full | The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma |
title_fullStr | The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma |
title_full_unstemmed | The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma |
title_short | The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma |
title_sort | clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922338/ https://www.ncbi.nlm.nih.gov/pubmed/24499297 http://dx.doi.org/10.1186/1476-4598-13-25 |
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