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A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma

PURPOSE: The analysis was designed to compare dosimetric parameters among 3-D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) and RapidArc (RA) to identify which can achieve the lowest risk of radiation-induced liver disease (RILD) for hepatocellular carcinoma (HCC). METHODS:...

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Autores principales: Chen, Dong, Wang, Renben, Meng, Xiangjiao, Liu, Tonghai, Yan, Hongjiang, Feng, Rui, Liu, Shangang, Jiang, Shumei, Xu, Xiaoqing, Zhu, Kunli, Dou, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922419/
https://www.ncbi.nlm.nih.gov/pubmed/24502643
http://dx.doi.org/10.1186/1748-717X-9-48
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author Chen, Dong
Wang, Renben
Meng, Xiangjiao
Liu, Tonghai
Yan, Hongjiang
Feng, Rui
Liu, Shangang
Jiang, Shumei
Xu, Xiaoqing
Zhu, Kunli
Dou, Xue
author_facet Chen, Dong
Wang, Renben
Meng, Xiangjiao
Liu, Tonghai
Yan, Hongjiang
Feng, Rui
Liu, Shangang
Jiang, Shumei
Xu, Xiaoqing
Zhu, Kunli
Dou, Xue
author_sort Chen, Dong
collection PubMed
description PURPOSE: The analysis was designed to compare dosimetric parameters among 3-D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) and RapidArc (RA) to identify which can achieve the lowest risk of radiation-induced liver disease (RILD) for hepatocellular carcinoma (HCC). METHODS: Twenty patients with HCC were enrolled in this study. Dosimetric values for 3DCRT, IMRT, and RA were calculated for total dose of 50 Gy/25f. The percentage of the normal liver volume receiving >40, >30, >20, >10, and >5 Gy (V(40), V(30), V(20), V(10) and V(5)) were evaluated to determine liver toxicity. V(5), V(10), V(20), V(30) and D(mean) of liver were compared as predicting parameters for RILD. Other parameters included the conformal index (CI), homogeneity index (HI), and hot spot (V(110%)) for the planned target volume (PTV) as well as the monitor units (MUs) for plan efficiency, the mean dose (D(mean)) for the organs at risk (OARs) and the maximal dose at 1% volume (D(1%)) for the spinal cord. RESULTS: The D(mean) of IMRT was higher than 3DCRT (p = 0.045). For V(5), there was a significant difference: RA > IMRT >3DCRT (p <0.05). 3DCRT had a lower V(10) and higher V(20), V(30) values for liver than RA (p <0.05). RA and IMRT achieved significantly better CI and lower V(110%) values than 3DCRT (p <0.05). RA had better HI, lower MUs and shorter delivery time than 3DCRT or IMRT (p <0.05). CONCLUSION: For right lobe tumors, RapidArc may have the lowest risk of RILD with the lowest V(20) and V(30) compared with 3DCRT or IMRT. For diameters of tumors >8 cm in our study, the value of D(mean) for 3DCRT was lower than IMRT or RapidArc. This may indicate that 3DCRT is more suitable for larger tumors.
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spelling pubmed-39224192014-02-13 A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma Chen, Dong Wang, Renben Meng, Xiangjiao Liu, Tonghai Yan, Hongjiang Feng, Rui Liu, Shangang Jiang, Shumei Xu, Xiaoqing Zhu, Kunli Dou, Xue Radiat Oncol Research PURPOSE: The analysis was designed to compare dosimetric parameters among 3-D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) and RapidArc (RA) to identify which can achieve the lowest risk of radiation-induced liver disease (RILD) for hepatocellular carcinoma (HCC). METHODS: Twenty patients with HCC were enrolled in this study. Dosimetric values for 3DCRT, IMRT, and RA were calculated for total dose of 50 Gy/25f. The percentage of the normal liver volume receiving >40, >30, >20, >10, and >5 Gy (V(40), V(30), V(20), V(10) and V(5)) were evaluated to determine liver toxicity. V(5), V(10), V(20), V(30) and D(mean) of liver were compared as predicting parameters for RILD. Other parameters included the conformal index (CI), homogeneity index (HI), and hot spot (V(110%)) for the planned target volume (PTV) as well as the monitor units (MUs) for plan efficiency, the mean dose (D(mean)) for the organs at risk (OARs) and the maximal dose at 1% volume (D(1%)) for the spinal cord. RESULTS: The D(mean) of IMRT was higher than 3DCRT (p = 0.045). For V(5), there was a significant difference: RA > IMRT >3DCRT (p <0.05). 3DCRT had a lower V(10) and higher V(20), V(30) values for liver than RA (p <0.05). RA and IMRT achieved significantly better CI and lower V(110%) values than 3DCRT (p <0.05). RA had better HI, lower MUs and shorter delivery time than 3DCRT or IMRT (p <0.05). CONCLUSION: For right lobe tumors, RapidArc may have the lowest risk of RILD with the lowest V(20) and V(30) compared with 3DCRT or IMRT. For diameters of tumors >8 cm in our study, the value of D(mean) for 3DCRT was lower than IMRT or RapidArc. This may indicate that 3DCRT is more suitable for larger tumors. BioMed Central 2014-02-06 /pmc/articles/PMC3922419/ /pubmed/24502643 http://dx.doi.org/10.1186/1748-717X-9-48 Text en Copyright © 2014 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Chen, Dong
Wang, Renben
Meng, Xiangjiao
Liu, Tonghai
Yan, Hongjiang
Feng, Rui
Liu, Shangang
Jiang, Shumei
Xu, Xiaoqing
Zhu, Kunli
Dou, Xue
A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma
title A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma
title_full A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma
title_fullStr A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma
title_full_unstemmed A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma
title_short A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma
title_sort comparison of liver protection among 3-d conformal radiotherapy, intensity-modulated radiotherapy and rapidarc for hepatocellular carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922419/
https://www.ncbi.nlm.nih.gov/pubmed/24502643
http://dx.doi.org/10.1186/1748-717X-9-48
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