High Cytotoxic Activity of Phosphonium Salts and Their Complementary Selectivity towards HeLa and K562 Cancer Cells: Identification of Tri-n-butyl-n-hexadecylphosphonium bromide as a Highly Potent Anti-HeLa Phosphonium Salt

Quaternary ammonium and phosphonium salts have been screened for their toxic effect on HeLa and K562 cancer cell lines, as well as on normal HUVEC cells. Tri-n-butyl-n-hexadecylphosphonium bromide, the first phosphonium salt with a halogen anion tested against HeLa cells, was 12 times more potent (I...

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Detalles Bibliográficos
Autores principales: Bachowska, Barbara, Kazmierczak-Baranska, Julia, Cieslak, Marcin, Nawrot, Barbara, Szczęsna, Dorota, Skalik, Joanna, Bałczewski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922438/
https://www.ncbi.nlm.nih.gov/pubmed/24551490
http://dx.doi.org/10.1002/open.201100003

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