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Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction

BACKGROUND: We sought to investigate the influence of the extent of myocardial injury on left ventricular (LV) systolic and diastolic function in patients after reperfused acute myocardial infarction (AMI). METHODS: Thirty-eight reperfused AMI patients underwent cardiac magnetic resonance (CMR) imag...

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Autores principales: Chung, Hyemoon, Yoon, Ji-Hyun, Yoon, Young Won, Park, Chul Hwan, Ko, Eun Jung, Kim, Jong Youn, Min, Pil-Ki, Kim, Tae Hoon, Lee, Byoung Kwon, Hong, Bum-Kee, Rim, Se-Joong, Kwon, Hyuck Moon, Choi, Eui-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922533/
https://www.ncbi.nlm.nih.gov/pubmed/24512272
http://dx.doi.org/10.1186/1476-7120-12-6
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author Chung, Hyemoon
Yoon, Ji-Hyun
Yoon, Young Won
Park, Chul Hwan
Ko, Eun Jung
Kim, Jong Youn
Min, Pil-Ki
Kim, Tae Hoon
Lee, Byoung Kwon
Hong, Bum-Kee
Rim, Se-Joong
Kwon, Hyuck Moon
Choi, Eui-Young
author_facet Chung, Hyemoon
Yoon, Ji-Hyun
Yoon, Young Won
Park, Chul Hwan
Ko, Eun Jung
Kim, Jong Youn
Min, Pil-Ki
Kim, Tae Hoon
Lee, Byoung Kwon
Hong, Bum-Kee
Rim, Se-Joong
Kwon, Hyuck Moon
Choi, Eui-Young
author_sort Chung, Hyemoon
collection PubMed
description BACKGROUND: We sought to investigate the influence of the extent of myocardial injury on left ventricular (LV) systolic and diastolic function in patients after reperfused acute myocardial infarction (AMI). METHODS: Thirty-eight reperfused AMI patients underwent cardiac magnetic resonance (CMR) imaging after percutaneous coronary revascularization. The extent of myocardial edema and scarring were assessed by T2 weighted imaging and late gadolinium enhancement (LGE) imaging, respectively. Within a day of CMR, echocardiography was done. Using 2D speckle tracking analysis, LV longitudinal, circumferential strain, and twist were measured. RESULTS: Extent of LGE were significantly correlated with LV systolic functional indices such as ejection fraction (r = -0.57, p < 0.001), regional wall motion score index (r = 0.52, p = 0.001), and global longitudinal strain (r = 0.56, p < 0.001). The diastolic functional indices significantly correlated with age (r = -0.64, p < 0.001), LV twist (r = -0.39, p = 0.02), average non-infarcted myocardial circumferential strain (r = -0.52, p = 0.001), and LV end-diastolic wall stress index (r = -0.47, p = 0.003 with e’) but not or weakly with extent of LGE. In multivariate analysis, age and non-infarcted myocardial circumferential strain independently correlated with diastolic functional indices rather than extent of injury. CONCLUSIONS: In patients with timely reperfused AMI, not only extent of myocardial injury but also age and non-infarcted myocardial function were more significantly related to LV chamber diastolic function.
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spelling pubmed-39225332014-02-13 Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction Chung, Hyemoon Yoon, Ji-Hyun Yoon, Young Won Park, Chul Hwan Ko, Eun Jung Kim, Jong Youn Min, Pil-Ki Kim, Tae Hoon Lee, Byoung Kwon Hong, Bum-Kee Rim, Se-Joong Kwon, Hyuck Moon Choi, Eui-Young Cardiovasc Ultrasound Research BACKGROUND: We sought to investigate the influence of the extent of myocardial injury on left ventricular (LV) systolic and diastolic function in patients after reperfused acute myocardial infarction (AMI). METHODS: Thirty-eight reperfused AMI patients underwent cardiac magnetic resonance (CMR) imaging after percutaneous coronary revascularization. The extent of myocardial edema and scarring were assessed by T2 weighted imaging and late gadolinium enhancement (LGE) imaging, respectively. Within a day of CMR, echocardiography was done. Using 2D speckle tracking analysis, LV longitudinal, circumferential strain, and twist were measured. RESULTS: Extent of LGE were significantly correlated with LV systolic functional indices such as ejection fraction (r = -0.57, p < 0.001), regional wall motion score index (r = 0.52, p = 0.001), and global longitudinal strain (r = 0.56, p < 0.001). The diastolic functional indices significantly correlated with age (r = -0.64, p < 0.001), LV twist (r = -0.39, p = 0.02), average non-infarcted myocardial circumferential strain (r = -0.52, p = 0.001), and LV end-diastolic wall stress index (r = -0.47, p = 0.003 with e’) but not or weakly with extent of LGE. In multivariate analysis, age and non-infarcted myocardial circumferential strain independently correlated with diastolic functional indices rather than extent of injury. CONCLUSIONS: In patients with timely reperfused AMI, not only extent of myocardial injury but also age and non-infarcted myocardial function were more significantly related to LV chamber diastolic function. BioMed Central 2014-02-10 /pmc/articles/PMC3922533/ /pubmed/24512272 http://dx.doi.org/10.1186/1476-7120-12-6 Text en Copyright © 2014 Chung et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Chung, Hyemoon
Yoon, Ji-Hyun
Yoon, Young Won
Park, Chul Hwan
Ko, Eun Jung
Kim, Jong Youn
Min, Pil-Ki
Kim, Tae Hoon
Lee, Byoung Kwon
Hong, Bum-Kee
Rim, Se-Joong
Kwon, Hyuck Moon
Choi, Eui-Young
Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction
title Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction
title_full Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction
title_fullStr Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction
title_full_unstemmed Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction
title_short Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction
title_sort different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922533/
https://www.ncbi.nlm.nih.gov/pubmed/24512272
http://dx.doi.org/10.1186/1476-7120-12-6
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