Cargando…

Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects

BACKGROUND: Nephrolithiasis is more frequent and severe in obese patients from different western nations. This may be supported by higher calcium, urate, oxalate excretion in obese stone formers. Except these parameters, clinical characteristics of obese stone formers were not extensively explored....

Descripción completa

Detalles Bibliográficos
Autores principales: Soldati, Laura, Bertoli, Simona, Terranegra, Annalisa, Brasacchio, Caterina, Mingione, Alessandra, Dogliotti, Elena, Raspini, Benedetta, Leone, Alessandro, Frau, Francesca, Vignati, Laila, Spadafranca, Angela, Vezzoli, Giuseppe, Cusi, Daniele, Battezzati, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922585/
https://www.ncbi.nlm.nih.gov/pubmed/24502605
http://dx.doi.org/10.1186/1479-5876-12-34
_version_ 1782303466866081792
author Soldati, Laura
Bertoli, Simona
Terranegra, Annalisa
Brasacchio, Caterina
Mingione, Alessandra
Dogliotti, Elena
Raspini, Benedetta
Leone, Alessandro
Frau, Francesca
Vignati, Laila
Spadafranca, Angela
Vezzoli, Giuseppe
Cusi, Daniele
Battezzati, Alberto
author_facet Soldati, Laura
Bertoli, Simona
Terranegra, Annalisa
Brasacchio, Caterina
Mingione, Alessandra
Dogliotti, Elena
Raspini, Benedetta
Leone, Alessandro
Frau, Francesca
Vignati, Laila
Spadafranca, Angela
Vezzoli, Giuseppe
Cusi, Daniele
Battezzati, Alberto
author_sort Soldati, Laura
collection PubMed
description BACKGROUND: Nephrolithiasis is more frequent and severe in obese patients from different western nations. This may be supported by higher calcium, urate, oxalate excretion in obese stone formers. Except these parameters, clinical characteristics of obese stone formers were not extensively explored. AIMS: In the present paper we studied the relationship between obesity and its metabolic correlates and nephrolithiasis. MATERIALS AND METHODS: We studied 478 Caucasian subjects having BMI ≥ 25 kg/m(2). The presence of nephrolithiasis, hypertension, diabetes mellitus and metabolic syndrome were noted. They underwent measurements of anthropometry (BMI and waist circumference, body composition), serum variables (fasting glucose, serum lipids and serum enzymes) and Mediterranean diet (MedDiet) nutritional questionnaire. RESULTS: 45 (9.4%) participants were stone formers. Subjects with high serum concentrations of triglycerides (≥150 mg/dl), fasting glucose (> 100 mg/dl) and AST (>30 U/I in F or >40 U/I in M) were more frequent among stone formers than non-stone formers. Multinomial logistic regression confirmed that kidney stone production was associated with high fasting glucose (OR = 2.6, 95% CI 1.2-5.2, P = 0.011), AST (OR = 4.3, 95% CI 1.1-16.7, P = 0.033) and triglycerides (OR = 2.7, 95% CI 1.3-5.7, P = 0.01). MedDiet score was not different in stone formers and non-stone formers. However, stone formers had a lower consumption frequency of olive oil and nuts, and higher consumption frequency of wine compared with non-stone formers. CONCLUSIONS: Overweight and obese stone formers may have a defect in glucose metabolism and a potential liver damage. Some foods typical of Mediterranean diet may protect against nephrolithiasis.
format Online
Article
Text
id pubmed-3922585
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-39225852014-02-13 Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects Soldati, Laura Bertoli, Simona Terranegra, Annalisa Brasacchio, Caterina Mingione, Alessandra Dogliotti, Elena Raspini, Benedetta Leone, Alessandro Frau, Francesca Vignati, Laila Spadafranca, Angela Vezzoli, Giuseppe Cusi, Daniele Battezzati, Alberto J Transl Med Research BACKGROUND: Nephrolithiasis is more frequent and severe in obese patients from different western nations. This may be supported by higher calcium, urate, oxalate excretion in obese stone formers. Except these parameters, clinical characteristics of obese stone formers were not extensively explored. AIMS: In the present paper we studied the relationship between obesity and its metabolic correlates and nephrolithiasis. MATERIALS AND METHODS: We studied 478 Caucasian subjects having BMI ≥ 25 kg/m(2). The presence of nephrolithiasis, hypertension, diabetes mellitus and metabolic syndrome were noted. They underwent measurements of anthropometry (BMI and waist circumference, body composition), serum variables (fasting glucose, serum lipids and serum enzymes) and Mediterranean diet (MedDiet) nutritional questionnaire. RESULTS: 45 (9.4%) participants were stone formers. Subjects with high serum concentrations of triglycerides (≥150 mg/dl), fasting glucose (> 100 mg/dl) and AST (>30 U/I in F or >40 U/I in M) were more frequent among stone formers than non-stone formers. Multinomial logistic regression confirmed that kidney stone production was associated with high fasting glucose (OR = 2.6, 95% CI 1.2-5.2, P = 0.011), AST (OR = 4.3, 95% CI 1.1-16.7, P = 0.033) and triglycerides (OR = 2.7, 95% CI 1.3-5.7, P = 0.01). MedDiet score was not different in stone formers and non-stone formers. However, stone formers had a lower consumption frequency of olive oil and nuts, and higher consumption frequency of wine compared with non-stone formers. CONCLUSIONS: Overweight and obese stone formers may have a defect in glucose metabolism and a potential liver damage. Some foods typical of Mediterranean diet may protect against nephrolithiasis. BioMed Central 2014-02-06 /pmc/articles/PMC3922585/ /pubmed/24502605 http://dx.doi.org/10.1186/1479-5876-12-34 Text en Copyright © 2014 Soldati et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Soldati, Laura
Bertoli, Simona
Terranegra, Annalisa
Brasacchio, Caterina
Mingione, Alessandra
Dogliotti, Elena
Raspini, Benedetta
Leone, Alessandro
Frau, Francesca
Vignati, Laila
Spadafranca, Angela
Vezzoli, Giuseppe
Cusi, Daniele
Battezzati, Alberto
Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects
title Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects
title_full Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects
title_fullStr Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects
title_full_unstemmed Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects
title_short Relevance of Mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects
title_sort relevance of mediterranean diet and glucose metabolism for nephrolithiasis in obese subjects
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922585/
https://www.ncbi.nlm.nih.gov/pubmed/24502605
http://dx.doi.org/10.1186/1479-5876-12-34
work_keys_str_mv AT soldatilaura relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT bertolisimona relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT terranegraannalisa relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT brasacchiocaterina relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT mingionealessandra relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT dogliottielena relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT raspinibenedetta relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT leonealessandro relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT fraufrancesca relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT vignatilaila relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT spadafrancaangela relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT vezzoligiuseppe relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT cusidaniele relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects
AT battezzatialberto relevanceofmediterraneandietandglucosemetabolismfornephrolithiasisinobesesubjects